UBB


Also found in: Acronyms, Wikipedia.

UBB

A gene on chromosome 17p12-p11.2 that encodes a ubiquitin. Ubiquitins are either covalently attached to another protein, or free (unanchored). When covalently bound, ubiquitin is conjugated to target proteins, either as a monomer (monoubiquitin), a polymer linked to different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chain). Polyubiquitin chains attached to a target protein have different functions depending on the Lys residue of the ubiquitin attached. Linear polymer chains formed by attaching to the initiator Met lead to cell signalling. Free (unanchored) polyubiquitin is involved in activating protein kinases and in signalling.

Polyubiquitin Lys residues and roles
• Lys-6-linked—DNA repair.
• Lys-11-linked—ERAD (endoplasmic reticulum-associated degradation) and cell-cycle regulation.
• Lys-29-linked—Lysosomal degradation.
• Lys-33-linked—Kinase modification.
• Lys-48-linked—Protein degradation via the proteasome.
• Lys-63-linked—Endocytosis, DNA-damage response, signalling leading to activation of the transcription factor NF-kappaB.
Mentioned in ?
References in periodicals archive ?
In turn, this will help operators, consumers, and content providers benefit from UBB development.
A NIOSH panel's review of MSHA's UBB accident report criticized the agency essentially for being too easy on itself for its role in the UBB tragedy.
Excluding the UBB related charge, the company reported a net loss of $1.
In this paper we are introducing the UBB idea and describing the issues related to the QoS in the last mile and making recommendations.
On-We Network Community Hosts (Co-Host), such as UBB, perform clearing and settlement functions for customers in their network community.
According to Mary Sherman, Vice President and UNETexchange manager for UBB, "Active Archive enables us to offer our respondent customers a tool to easily and efficiently manage their data and automate the process of returns and adjustments.
UBB-AIG was set up as a bank-assurance company for UBB in 2006.
Monday All-Stars beat Master Mind 70-58; Al Zayani beat Saturday Blazers 55-50; Philippine Friends Restaurant/Dabarkadz 'B' beat Reem 46-41; Al Ghanah beat Cebarco 46-29; KIB beat Ric's Kountry Kitchen 44-40; Verminex beat Cathay Pacific 60-52; Zenjex beat Bahrain International Circuit 57-53; La Meza beat Ratsky 47-43; Hoops beat Alamid 63-39; Voit beat Baraka 99-71, Sunny Vale/Takusa beat UBB 50-42; Porsche beat SULB 68-53; Bahrain Limo beat Havelock AHI 54-42.
Recall that the NIOSH independent panel charged with evaluating MSHA's review of its performance at UBB faulted agency accident investigators for asking leading questions and being unfocused at times in their interrogations.
At UBB Club Vassil Petrov, The Pop Project - September 3, 9pm.
The 70-year-old TV pundit admitted he was only in UBB for the cash.