UBA3

UBA3

A gene on chromosome 3p24.3-p13 that encodes the ubiquitous catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme, which activates NEDD8 and transfers it to the catalytic cysteine of UBE2M, where it downregulates steroid receptor activity. UBA3 is required for cell cycle progression.
References in periodicals archive ?
Of the 14 proteins found in only some groups, seven (Sacsin, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3, KIAA0591 protein, metabotropic glutamate receptor 5 isoform b precursor, UBA3, vacuolar protein sorting-associated protein 45, and E3 ubiquitin-protein ligase HECTD1) were only found in patients groups and were absent from controls, although the level of the 7 proteins was similar between the patient groups (data not shown).