UBA3

A gene on chromosome 3p24.3-p13 that encodes the ubiquitous catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme, which activates NEDD8 and transfers it to the catalytic cysteine of UBE2M, where it downregulates steroid receptor activity. UBA3 is required for cell cycle progression.

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Of the 14 proteins found in only some groups, seven (Sacsin, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3, KIAA0591 protein, metabotropic glutamate receptor 5 isoform b precursor, UBA3, vacuolar protein sorting-associated protein 45, and E3 ubiquitin-protein ligase HECTD1) were only found in patients groups and were absent from controls, although the level of the 7 proteins was similar between the patient groups (data not shown).

Proteomic analysis of serum and urine of HIV-monoinfected and HIV/HCV-coinfected patients undergoing long term treatment with nevirapine

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