PRPF6

(redirected from U5-102K)

PRPF6

A gene on chromosome 20q13.33 that encodes protein involved in pre-mRNA splicing, which may be required in the tri-snRNP complex as a bridging factor between U5 and U4/U6 snRNPs in the late step of spliceosome assembly. It enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1.

Molecular pathology
Defects in PRPF6 cause retinitis pigmentosa type 60.
References in classic literature ?
Wouldst thou have said `Yes', then, if I had spoken?
Am I a cannon-ball, Stubb, said Ahab, that thou wouldst wad me that fashion?
But, mastering his emotion, he half calmly rose, and as he quitted the cabin, paused for an instant and said: Thou hast outraged, not insulted me, Sir; but for that I ask thee not to beware of Starbuck; thou wouldst but laugh; but let Ahab beware of Ahab; beware of thyself, old man.
What, wouldst have me let thee, of all men, escape and not hang with us, when thou'rt the very CAUSE of our hanging?
If thou hadst loved me truly thou wouldst not have stood me up in the corner.
As to thee," pursued madame, implacably, addressing her husband, "if it depended on thee--which, happily, it does not--thou wouldst rescue this man even now.
Then thou badest me come to thee when thou hadst grown great, vowing that thou wouldst protect me and never do me harm.
Thou wouldst thy self, no doubt, And boldly venture to whatever place Farthest from pain, where thou mightst hope to change Torment with ease, & soonest recompence Dole with delight, which in this place I sought; To thee no reason; who knowst only good, But evil hast not tri'd: and wilt object His will who bound us?
Gurth,'' said the Jester, ``I know thou thinkest me a fool, or thou wouldst not be so rash in putting thy head into my mouth.
If, therefore, thou wouldst have me enjoy what can be called life, thou wilt at once engage in this love struggle, not lukewarmly nor slothfully, but with the energy and zeal that my desire demands, and with the loyalty our friendship assures me of.
Say quickly what thou wouldst have of me, for there is but a short hour that we may tarry here.
I should be as thankful t' have her for a sister as thee wouldst t' have her for a daughter.