Tysabri

natalizumab

(na-ta-li-zoo-mab) ,

Tysabri

(trade name)

Classification

Therapeutic: anti multiple sclerosis agents
Pharmacologic: monoclonal antibodies
Pregnancy Category: C

Indications

To reduce the frequency of exacerbations of relapsing multiple sclerosis.Inducing and maintaining remission in moderately to severely active Crohn's disease in patients who have been unresponsive to conventional therapies, including tumor-necrosis factor inhibitors.

Action

Binds to integrin receptors on non-neutrophil leukocytes which may alter adhesion and migration characteristics involved in the crossing of activated inflammatory cells into the CNS.

Therapeutic effects

Fewer exacerbations of relapsing multiple sclerosis.

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: 7–15 days.

Time/action profile

ROUTEONSETPEAKDURATION
IVunknownunknownunknown

Contraindications/Precautions

Contraindicated in: Hypersensitivity; Concurrent use of immunosupressants or tumor-necrosis factor inhibitors; History of progressive multifocal leukoencephalopathy (PML); Pediatric: Children <18 yr.
Use Cautiously in: Anti-JC virus (JCV) positive Obstetric: Use only if clearly needed.

Adverse Reactions/Side Effects

Central nervous system

  • depression
  • fatigue

Gastrointestinal

  • hepatotoxicity (life-threatening)
  • cholelithiasis

Dermatologic

  • melanoma

Miscellaneous

  • allergic reactions including anaphylaxis
  • infections
  • PML (life-threatening)
  • infusion-related reactions

Interactions

Drug-Drug interaction

↑ risk of infection with immunosupressants (avoid concurrent use).

Route/Dosage

NOTE: Because of the risk of PML, natalizumab is available only under a special restricted distribution program, the TOUCH Prescribing Program. Prescribers, pharmacies, and patients must be enrolled in the program to obtain the drug.

Multiple Sclerosis

Intravenous (Adults) 300 mg every 4 wk.

Crohn's Disease

Intravenous (Adults) 300 mg every 4 wk; if no response after 12 wk, or if patient cannot be tapered off corticosteroid therapy after 6 mo, discontinue therapy.

Availability

Solution for injection: 300 mg/15 mL

Nursing implications

Nursing assessment

  • Observe patient during infusion and for 1 hr after infusion is completed. Assess for signs of hypersensitivity reactions (urticaria, dizziness, fever, rash, rigors, pruritus, nausea, flushing, hypotension, dyspnea, chest pain, anaphylaxis), especially during first 2 hrs of infusion. If symptoms occur, discontinue natalizumab and treat symptoms.
  • Assess for new signs or symptoms suggestive of PML, an opportunistic infection of the brain caused by the JC virus, leading to death or severe disability; withhold dose and notify health care professional promptly. Monitor during therapy and for at least 6 months following discontinuation. PML symptoms may begin gradually but usually worsen rapidly. Symptoms vary depending on which part of the brain is infected (mental function declines rapidly and progressively, causing dementia; speaking becomes increasingly difficult; partial blindness; difficulty walking; rarely, headaches and seizures occur). Diagnosis is usually made via gadolinium-enhanced MRI and CSF analysis. Risk of PML increases with the number of infusions. Withhold natalizumab at first sign of PML.
  • Obtain an MRI of the brain prior to initiating therapy to help in differentiating symptoms of MS with those of PML.
  • MS: Assess frequency of exacerbations of symptoms of multiple sclerosis periodically during therapy.
  • Crohn's disease: Assess abdominal pain and frequency, quantity, and consistency of stools at beginning and during therapy.
  • Lab Test Considerations: May cause ↑ lymphocytes, monocytes, eosinophils, basophils, and nucleated RBCs. These ↑ persist during therapy but usually return to baseline within 16 weeks after last dose. Neutrophil ↑ do not usually occur.
    • May cause hepatotoxicity. Monitor for ↑ serum hepatic enzymes and total bilirubin may occur within 6 days after the first dose or for the first time after multiple doses. Discontinue if jaundice or other evidence of hepatotoxicity occurs.
    • Monitor serum JCV antibodies periodically during therapy. Patients with a negative antibody should be retested periodically during therapy due potential for false-positive results or a new infection.

Potential Nursing Diagnoses

Deficient knowledge, related to medication regimen (Patient/Family Teaching)

Implementation

  • Intravenous Administration
  • Intermittent Infusion: Diluent: Dilute 300 mg in 100 mL of 0.9% NaCl. Invert to mix solution; do not shake. Do not mix with other diluents. Solution is colorless and clear to slightly opalescent. Do not administer solutions that are discolored or contain particulate matter. Administer immediately after dilution or refrigerate and use within 8 hrs. Concentration: 2.6 mg/mL.
  • Rate: Infuse over 1 hr. Do not use filtration devices. Do not administer as IV push or bolus injection.

Patient/Family Teaching

  • Inform patient of purpose of medication. Patients must visit their health care professional/prescriber 3 and 6 months after first infusion and every 6 months thereafter for follow-up exam.
  • Instruct patient to read the Medication Guide before starting the infusion. Natalizumab is available only through a special restricted distribution program called the TOUCH™ Prescribing Program, MS-TOUCH for multiple sclerosis and CD-TOUCH for Crohn's Disease, and must be administered only to patients enrolled in this program.
  • Instruct patient to report symptoms of PML (progressive weakness on one side of the body or clumsiness of limbs; disturbance of vision; changes in thinking, memory, and orientation leading to confusion and personality changes), hypersensitivity reactions, hepatotoxicity (yellowing of the skin and eyes, unusual darkening of the urine, nausea, feeling tired or weak, vomiting), or worsening of symptoms (new or sudden change in your thinking, eyesight, balance, or strength or other problems) that persist over several days to health care professional immediately.
  • Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
  • Instruct patient to inform all health care professionals about treatment with natalizumab.
  • Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

  • Decrease in frequency of clinical exacerbations in patients with multiple sclerosis.
  • Decrease in signs and symptoms of Crohn's disease.
  • Patients must be evaluated at 3 mo and 6 mo after first infusion and every 6 mo thereafter to determine effectiveness.
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References in periodicals archive ?
Optimism was also expressed for Tysabri, another multiple sclerosis treatment.
But she was denied the only drug that could help, Tysabri, by Welsh Assembly Government health chiefs.
The latest MS drug to be approved for use on the NHS, Tysabri, costs pounds 14,000 per year, but also requires patients who suffer from frequent severe attacks to be admitted to hospital 12 times a year for treatment.
* Additional data from a trial with 942 volunteers who received Tysabri or a placebo infusion affirmed earlier good outcomes.
Natalizumab, an immune-modulator marketed as Tysabri by Biogen Idec, was taken off the market in February 2005--3 months after its approval for management of relapsing MS--after it was linked to PML, a rare, usually fatal demyelinating CNS infection, in three patients.
The drug was marketed as Tysabri by Biogen Idee of Cambridge, Mass., and Elan Corp.
This past year, Celebrex and Bextra, in the same class as Vioxx, made headlines for their adverse effects; and in February, sales of the multiple sclerosis drug Tysabri were suspended after it was suspected of triggering a rare brain disease in three patients, two of whom died from the disease.
Drug delivery tysabri, supplement 300mg inf cnc sol 1x15ml, unit 1x15ml, quantity 1000
M2 EQUITYBITES-November 10, 2016-Perrigo Company appoints Morgan Stanley to lead review of strategic alternatives for Tysabri royalty stream
Headquartered in Ireland, the company is a manufacturer of OTC products and supplier of infant formulas for the store brand market; It is provider of generic extended topical prescription products and receives royalties from Multiple Sclerosis drug Tysabri; As well as provides Quality Affordable Healthcare Products across a wide variety of product categories and geographies primarily in North America, Europe, and Australia, and other markets, including Israel, China and Latin America.
The target rejected the offer, saying it was highly conditional and opportunistic as its timing did not give shareholders enough time to assess the benefits of the USD3.5bn sale of 50% in its Tysabri product to partner Biogen Idec Inc (NASDAQ:BIIB).
The only consolation was Michelle was to be started on disease-modifying drug (DMD) Tysabri - a drug only available for those suffering from a more advanced type of MS.