tyrosine kinase

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ty·ro·sine ki·nase

an enzyme that phosphorylates tyrosyl residues on certain proteins; many are products of viral oncogenes; a number of receptors (for example, receptors for epidermal growth factor, insulin, etc.) have this enzymatic activity; a misnomer, in that the physiologic substrate is not tyrosine but tyrosyl residues in a protein.

tyrosine kinase

n.
Any of a family of enzymes that phosphorylate tyrosine in certain proteins and play an important role in cell signaling. Mutations that affect their activity or expression can cause leukemia and other cancers.

tyrosine kinase

An enzyme intimately linked to signal transduction–ST, either as a receptor-type TK, which participates in transmembrane signaling, or as an intracellular TK, participating in ST to the nucleus; ↑ or ↓ TK activity is associated with various diseases, and alteration of TK activity at various points in its signaling pathway is of potential therapeutic interest; ↑ TK activity implicated in many CAs and other malignant and nonmalignant diseases, ASHD, psoriasis, inflammation; ↓ TK activity is linked to DM, X-linked agammaglobulinemia

tyrosine kinase

Any of a group of enzymes that influence signaling between cells, esp. as relates to cell growth and death, cellular adhesion and movement, and cellular differentiation. Abnormalities in tyrosine kinases are found in some human diseases, including chronic myeloid (myelogenous) leukemia.
See also: kinase
References in periodicals archive ?
The patients must be previously treated with imatinib and one or two additional tyrosine kinase inhibitors.
There are four cytoplasmic tyrosine kinases which are Jak 1, Jak 2, Jak 3 and TYK 2.
Dasatinib is a second-generation potent and efficacious oral tyrosine kinase inhibitor, frequently used for imatinib-resistant or -intolerant BCR-ABL--positive chronic myeloid leukemia (CML) and for Philadelphia chromosome-positive acute lymphocytic leukemia (1).
Since our present data indicates that STKs and Syk act posttranscriptionally towards this response, we investigated whether these tyrosine kinases might affect some of the translational events, which we identified in previous studies.
Dobutamine's pharmacologic function does not depend on tyrosine kinases but rather on G-protein coupled receptors.
Recent guidelines from International Association for the Study of Lung Cancer/Association for Molecular Pathology/College of American Pathologists recommend at minimum EGFR and anaplastic lymphoma receptor tyrosine kinase (ALK) testing on all tumors with adenocarcinoma histology (including adenosquamous, adeno--small cell neuroendocrine, and poorly differentiated) (1).
The themes are historical perspectives, principles of cellular signaling by receptor tyrosine kinases (RTKs), specific molecular features and mechanisms of key RTK families, development, and disease and medicine.
Chronic myeloid leukemia (CML) is a chronic myeloproliferative disease characterized by tyrosine kinase activity caused by translocation between chromosomes 9 and 22 [1].
Hoshiyama et al., "Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra," Journal of Molecular Evolution, vol.
Alitalo, "Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response," Oncogene, vol.
The latter hosts the tyrosine kinase (TK) catalytic domain (amino acids 683-958) which is flanked by a juxtamembrane (JM) domain (amino acids 645-682) and the C-terminal tail (amino acids 992 and 1186) containing the key tyrosine residues of autophosphorylation [2].
Receptor tyrosine kinases are critical signaltransduction mediators regulating essential cellular activities including growth, differentiation and migration, as well as survival and death (1).

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