TYK2

(redirected from Tyrosine kinase 2)
Also found in: Wikipedia.

TYK2

A gene on chromosome 19p13.2 that encodes a non-receptor protein tyrosine kinase, which phosphorylates IFN-alpha/beta receptor alpha chains and may be involved in intracellular signal transduction by initiating type-I IFN signalling.

Molecular pathology
TYK2 defects cause protein-tyrosine kinase 2 deficiency.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Bristol-Myers announced results from a Phase 2 study of BMS-986165, an investigational oral, selective tyrosine kinase 2 inhibitor, in patients with moderate to severe plaque psoriasis.
Serial sequencing of cfDNA could lead to the discovery of molecular resistance mechanisms and the identification of new therapeutic targets [for example, MET proto-oncogene, receptor tyrosine kinase (MET) and erb-b2 receptor tyrosine kinase 2 (ERBB2) amplification as a resistance mechanism to EGFR inhibition in metastatic colorectal cancer, and the acquisition of EGFR T790M mutation in lung cancers treated with early-generation EGFR tyrosine kinase inhibitors] (3).
[3] Human genes: IDH1, isocitrate dehydrogenase 1; IDH2, isocitrate dehydrogenase 2; MET, MET proto-oncogene, receptor tyrosine kinase; ERBB2, erb-b2 receptor tyrosine kinase 2; EGFR, epidermal growth factor receptor; TP53, tumor protein p53; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; KRAS, Kirsten rat sarcoma viral oncogene homolog; ALK, anaplastic lymphoma receptor tyrosine kinase; BRAF, b-raf proto-oncogene, serine/threonine kinase.
Exposure to R5 gp120 and X4 gp 120 resulted in activation of pro line-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase related to focal adhesion kinase.
EGFR exon 20 insertion mutations are mutually exclusive from other well-identified oncogenic driver mutations seen in lung adenocarcinoma [e.g., KRAS (Kirsten rat sarcoma viral oncogene homolog), ERBB2 (erb-b2 receptor tyrosine kinase 2), BRAF(B-Raf protooncogene, serine/threonine kinase), and ALK fusions] (4, 6).

Full browser ?