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Related to Tyrosine hydroxylase: DOPA decarboxylase


a chemical element, atomic number 90, atomic weight 232.038, symbol Th. (See Appendix 6.)
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


1. Abbreviation for T-helper cells , under cell.
2. Symbol for thorium.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 11p15.5 that encodes tyrosine hydroxylase, which plays a key role in adrenergic system physiology (e.g., catecholamine and dopamine synthesis).

Molecular pathology
Defects in TH cause Segawa syndrome autosomal recessive.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Symbol for thorium.


Abbreviation for T-helper cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Patient discussion about Th

Q. I received a corticosteroid injection in my left knne th A.M. Knee is all stiff & swollen. Is this normal?

A. actually you might have already had an arthritis in your knee before, then your doctor injected you with a corticosteroid into the affected joint. usually you will feel better (less pain) in your affected joint. if the symptoms don't improve then I suggest you to go see your specialist for further advise and treatment.

More discussions about Th
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References in periodicals archive ?
Feve, "Current status of tyrosine hydroxylase in management of Parkinson's disease," CNS and Neurological Disorders--Drug Targets, vol.
Wang et al., "Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease," Human Gene Therapy, vol.
After centrifugation at about 400-600 X g for 5-10 s using a standard benchtop centrifuge, the supernatant was removed, and the tissues were fixed for 4-12 h, either in 4% paraformaldehyde in 0.1 mol [1.sup.-1] phosphate buffer (pH 7.4) at 4[degrees] C for eventual detection of 5-HT or FMRFamide-related peptides, or in methanol at -18[degrees] C for the detection of tyrosine hydroxylase (TH).
Brain tissue samples were collected and stained with Tyrosine hydroxylase. Cell counts and fiber grades were performed on each tissue sample.
The animals were terminated at 16-18 weeks and kidneys and adrenals removed for the estimation of tyrosine hydroxylase activity by HPLC.
One pterin, tetrahydrobiopterin (BH4), is a necessary cofactor for tyrosine hydroxylase (TH) which is involved in neurotransmitter biosynthesis.
Pathologic studies on the brains of 2 patients who died from causes unrelated to their transplants indicated that both had "robust survival of tyrosine hydroxylase immunuoreactive cells and abundant reinnervation of the postcommissural putamen," Hauser and colleagues wrote.
In comparing the NGF-mediated induction of tyrosine hydroxylase (TH) activity and of neurite outgrowth in cultures of adrenal chromaffin cells from fetal, neonatal, and adult bovine animals, Naujoks et al.
In test-tube studies, the scientists found that the phthalide compound blocks the action of an enzyme called tyrosine hydroxylase, which the body used to produce catecholamines.
DA is synthesized from the amino acid tyrosine that crosses the blood-brain barrier, is transformed into L-3,4- dihydroxyphenylalanine (L-DOPA) by tyrosine hydroxylase and then, to DA by dopadecarboxylase.