NTRK1

(redirected from Tyrosine Kinase Receptor)
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NTRK1

A gene on chromosome 1q21-q22 that encodes neurotrophic tyrosine kinase receptor type 1 (TrkA) which, after neurotrophin binding, phosphorylates itself (autophosphorylates) and members of the MAPK pathway. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in neurotransmitter synthesis. It is involved in cell differentiation and may play a role in specifying sensory neuron subtypes.

Molecular pathology
NTRK1 mutations are associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviour, mental retardation and cancer.
References in periodicals archive ?
Grb10 plays a pivotal role in multiple intracellular transduction pathways after binding to activated tyrosine kinase receptors (LUCAS-FERNANDEZ et al., 2008).
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The PI3K/Akt pathway is a downstream target of the EGFR family and other tyrosine kinase receptors. Once activated by PI3K, Akt1 promotes cell cycle progression, inhibits apoptosis, induces protein synthesis, and triggers mTORC1--promoting cell growth via mitochondrial biogenesis and lipid synthesis [44,45].
Critical receptors that play a role in normal cell proliferation are known as tyrosine kinase receptors. Tyrosine kinase receptors are proteins located in the cell's outer plasma membrane and are awakened when they come into contact with a ligand.
Even in the case of Gleevec, some patients relapsed because new mutations in the tyrosine kinase receptor rendered them resistant to the effects of the drug.
Citing MET tyrosine kinase receptor dysfunction in autism and its role in cortical growth/gastrointestinal repair compounds the error since nonclinical scientists have associated every chromosome and more than 50 genes with an "autism" undifferentiated by sign, symptom, or syndrome.
Crosstalk between the oestrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance.
KaloBios chief scientific officer and co-inventor, Dr Geoffrey Yarranton, stated that EphA3 is a tyrosine kinase receptor that is expressed on hematologic cancers and solid tumours, including tumour stem cells, but not on normal blood or bone marrow stem cells.
CD117, a transmembrane tyrosine kinase receptor, has the same general structure as: a.
HCE proteins in the deal include members of the human TGF beta, Fibroblast Growth Factor (FGF), Hematopoietin and Interleukin, and Tyrosine Kinase Receptor Signaling families, and TNF-alpha.
CD117 is a transmembrane tyrosine kinase receptor that is encoded by the proto-oncogene c-kit.
Geoffrey Yarranton commented that EphA3 is a tyrosine kinase receptor expressed on haematologic cancers and solid tumours, including tumour stem cells, but not on normal blood or bone marrow stem cells.

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