type IV collagen


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type IV col·la·gen

a less distinctly fibrillar form of collagen characteristic of the lamina densa of the basal lamina.
References in periodicals archive ?
Type IV collagen induces down-regulation of steroidogenic response to gonadotropins in adult rat Leydig cells involving mitogen-activated protein kinase.
Type IV collagen, a network-forming collagen type,14 and laminins are the most abundant building blocks of the basement membrane.
The antibodies that we used in this study were as follows: p63 antibody (#sc-8431, Santa Cruz Biotechnology, Santa Cruz, CA), proliferating cell nuclear antigen antibody (PCNA, #M0879, DAKO, Glostrup, Denmark), integrin [alpha]6 antibody (#sc-6597, Santa Cruz Biotechnology), integrin [beta]1 antibody (#sc-9970, Santa Cruz Biotechnology), and type IV collagen antibody (239M-16, Cell Marque, Rocklin, CA).
Assessment of type IV collagen in serum helps in the evaluation of the level of progression of hepatic fibrosis and the diagnosis of cirrhosis, as well as aids the selection of a treatment regimen for hepatitis C and the prediction of the risk of carcinogenesis.
The serum levels of alanine transaminase (ALT), aspartate transaminase (AST), hyaluronic acid (HA), laminin (LN), type ill precollagen (PCIII) and type IV collagen (CIV) were measured using commercially available kits (Wuhan Boster Bio-Engineering Limited Company, Wuhan, China) and performed according to the manufacturer's protocol.
Type IV collagen stained the cell membrane of individual glomus cells (Figure 2, E).
In skin and connective tissues, CMG2 binds to type IV collagen and laminins, and is considered a factor to basement membrane strength.
MMP9 can degrade normal collagens such as gelatin, elastin, collagen type IV collagen, type V collagen and mucin but has no influence on abnormal collagens [5].
The intercalated discs and the lateral borders were visualised by antibodies against cadherin and type IV collagen (for details see Bruel et al.
A major component of basement membranes is type IV collagen, which provides a strong, cross-linked mesh material that lends strong structural support.
A new molecular method is the non-invasive DermGene biopsy technique which measures mRNA of important skeletal skin constituents (pro-collagen, Type IV collagen, fibronectin) and other biochemical changes associated with the renewal of the outer layers of the skin and resulting diminishment of wrinkle appearance.