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In the latter patients, including children with a complicated and/or severe initial presentation and a history/confirmation of immediate type 1 hypersensitivity response to penicillin, levofloxacin is recommended as an alternative to amoxicillin-clavulanate or ceftriaxone.
If the antigen or allergen is encountered again, mast cells undergo a degranulation, releasing their mediators into the surrounding tissue and triggering the symptoms of a type 1 hypersensitivity reaction.
Migraine has been investigated as type 1 hypersensitivity in studies in which high levels of total IgE and food-associated IgE in serums of patients with migraine have been found (6).