mutant gene theory

(redirected from Two-hit hypothesis)
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mutant gene theory

A paradigm for explaining carcinogenesis, which holds, in essence, that cancer results from an accumulation of mutations that:
(1) knock out or delete tumour suppressor genes (e.g., RB, p53, APC); and/or
(2) increase the activity of oncogenes (e.g., BRAF, c-erbb3, c-fos), whose protein products prompt cells to cancer progression.
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References in periodicals archive ?
In accordance with the two-hit hypothesis of schizophrenia, a combination of genetic susceptibility combined with a distinct developmental insult can ultimately lead to the occurrence of a full clinical syndrome.15
Martinez-Zamora concluded that the findings of the current study support the "two-hit hypothesis," used to explain why thrombotic events occur only occasionally, despite the persistent presence of APL.