Some of the major DNA vaccines include GlaxoSmithKline's Engerix-B, Twinrix
, and Fendrix; Merck's Gardasil, and Recombivax HB; Protein Sciences Corporation's Flublok, etc.
HepB vaccine is also available in 2 combination products: Pediarix, containing HepB, diphtheria and tetanus toxoids, acellular pertussis, and inactivated poliovirus (GlaxoSmithKline), approved for use in children 6 weeks to 6 years old; and Twinrix
(GlaxoSmithKline), which contains both HepB and HepA and is approved for use in adults 18 years and older.
In October 2018, ACIP recommended adding homelessness as an indication for routine hepatitis A vaccination with a 2-dose series of single-antigen hepatitis A vaccine (Havrix, GlaxoSmithKline; Vaqta, Merck) or a 3-dose series of combination hepatitis A and hepatitis B vaccine (Twinrix
, GlaxoSmithKline) (6).
GlaxoSmithKline is also conducting three other registries: the Belimumab (Benlysta) Pregnancy Registry for patients with systemic lupus erythematosus treated with belimumab (877-681-6296 / belimumab.pregnancy@ ppdi.com); and the Twinrix
Pregnancy Registry for women who have received the Twinrix
hepatitis A and B vaccine (888-825-5249).
The two vaccines, Twinrix
and Engerix-B, are officially approved for clinical use and are commercially available worldwide and in China.
There are currently three licensed hepatitis B vaccines for adults in the U.S.: the single antigen Recombivax HB (Merck) and Engerix-B (GlaxoSmithKline Biological) preparations and the combination vaccine Twinrix
In the meantime, the Centers for Disease Control and Prevention has reported that the pediatric formulation and adult formulation of GlaxoSmithKline's hepatitis A vaccine Havrix, and its adult hepatitis A/hepatitis B combination vaccine (Twinrix
), "are currently in good supply to meet demand."
In the meantime, the Centers for Disease Control and Prevention reported, the pediatric and adult formulations of GlaxoSmithKline's hepatitis A vaccine Havrix, and its adult hepatitis A/hepatitis B combination vaccine (Twinrix
) "'are currently in good supply to meet demand."
Safe and effective vaccines are available for HAV and HBV, including a new combination vaccine (Twinrix
Hepatitis A Inactivated & Hepatitis B), but a vaccine for HCV is considered years away because the virus mutates, or changes, so easily.
For persons who also require hepatitis B vaccination, a combined hepatitis A- hepatitis B vaccine (Twinrix
) provides a convenient three-dose method of vaccination.