Tuskeegee Study

A prospective study conducted by the US Public Health Service from 1932 to 1972 in Tuskeegee, Alabama, on a cohort of 400 black men, which examined the long-term effects of not treating their latent seropositive syphilis. It is considered one of the most egregious acts in the history of US medicine.
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The African American community's experiences with the Tuskeegee study and the sexual-orientation minority community's (lesbian, gay male, bisexual, and transgender) experiences with forced interventions such as castration, confinement in institutions, and aversion therapy re-enforce distrust in these communities and result in reluctance to cooperate with government and medical institutions (Benedek, 1978; Katz, 1994).
The 'Tuskeegee Study' of syphilis: Analysis of moral versus methodologic aspects.