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(klok) a device for measuring time.
biological clock  the physiologic mechanism which governs the rhythmic occurrence of certain biochemical, physiologic, and behavioral phenomena in living organisms.


1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.


A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.


A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: Hope this helps.

More discussions about clock
References in periodicals archive ?
Now you've got the BNP trying to turn back the clock.
In the same breath you slam Bush for wanting to turn back the clock on gay rights, then correctly point out that Kerry supports similar (if not the same) viewpoints.
To turn back the clock, two molecular biologists have harnessed a technique called molecular evolution (SN: 8/7/93, p.
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MARK HUGHESwants Blackburn to turn back the clock on and off the pitch when they take on Greek side Larissa tonight.
Among the attractions are the Red Devils Free-fall Parachute Team, the Royal Signals White Helmets Motorcycle Display Team and for the first time, Gothic Renaissance, a team of historic re-enactors who will turn back the clock 200 years to the time of Napoleon and the Peninsular War.
IT'S time to mix the cocktails and enjoy the elegance of the 1920s as Warwickshire performers turn back the clock for a comedy classic.
Who would have believed four years ago that in today's America, our government can search library records to see what we are reading, detain prisoners indefinitely without access to counsel, and turn back the clock on Roe v.
Best are hard-rock hits Blackout and Bad Boys Running Wild, which blazed a trail for The Darkness, but more recent attempts to turn back the clock, such as Mysterious, pale by comparison.