Tumor-suppressor gene


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Related to Tumor-suppressor gene: oncogene, Tumor suppressor proteins

Tumor-suppressor gene

Gene involved in controlling normal cell growth and preventing cancer.
Mentioned in: Retinoblastoma
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Fus1 is a tumor-suppressor gene shown to inhibit the growth of tumors and greatly reduce the spread of lung cancer in animals.
The p53 gene is a tumor-suppressor gene, which stops cell division, and is found in normal cells.
A new potential tumor-suppressor gene, NOEY2, has been associated with ovarian and breast cancers.
Previous research suggested that DCC acts as a tumor-suppressor gene because, as its name implies, it's frequently missing in people with colorectal cancer.
A team headed by Ronald DePinho of Dana-Farber Cancer Institute in Boston has crossed the KRAS-mutant mice with mice lacking a tumor-suppressor gene implicated in pancreatic cancer.
Introgen's ADVEXIN therapy is a patented cancer therapeutic incorporating the p53 tumor-suppressor gene in an adenoviral delivery system.
Evans, a Howard Hughes Medical Institute investigator at the Salk Institute for Biological Studies in La Jolla, Calif., tested such compounds on mice with mutations in a tumor-suppressor gene called APC.
While Merck has placed its bet on the Ras gene, another company has focused on a different molecular aspect of cancer--abnormalities in a tumor-suppressor gene called p53.
One strain, known as knockout mice, possesses a single functioning p53 tumor-suppressor gene in each cell; normal cells have two.
The group's data show that the tumor-suppressor gene p53 plays a key role in the genesis of squamous cell cancer.

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