Tumor-suppressor gene


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Related to Tumor-suppressor gene: oncogene, Tumor suppressor proteins

Tumor-suppressor gene

Gene involved in controlling normal cell growth and preventing cancer.
Mentioned in: Retinoblastoma
References in periodicals archive ?
Decades ago, cancer geneticists latched on to an attractively simple model in which only two types of genes control the disease's spread: Oncogenes trigger cancers and their growth, but tumor-suppressor genes keep cancer cells in check.
Introgen's ADVEXIN therapy is a patented cancer therapeutic incorporating the p53 tumor-suppressor gene in an adenoviral delivery system.
tested such compounds on mice with mutations in a tumor-suppressor gene called APC.
While Merck has placed its bet on the Ras gene, another company has focused on a different molecular aspect of cancer--abnormalities in a tumor-suppressor gene called p53.
One strain, known as knockout mice, possesses a single functioning p53 tumor-suppressor gene in each cell; normal cells have two.
The group's data show that the tumor-suppressor gene p53 plays a key role in the genesis of squamous cell cancer.
Finally, the tumor-suppressor gene p53, which is often defective in cancer cells, seems involved in some nerve cell death, says Shahin Sakhi of the University of Southern California School of Medicine in Los Angeles.

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