Tumor-suppressor gene


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Related to Tumor-suppressor gene: oncogene, Tumor suppressor proteins

Tumor-suppressor gene

Gene involved in controlling normal cell growth and preventing cancer.
Mentioned in: Retinoblastoma
References in periodicals archive ?
Cancer researchers tracked down a metastasis-suppressor gene (145: 222), discovered that an inactivated tumor-suppressor gene, maspin, could lead to breast cancer (145: 69), and found that the anticancer drug tamoxifen shuts down a tumor's blood supply (146: 292).
Some scientists believe BRCA1 acts as a tumor-suppressor gene -- one that provides the blueprint for a protein that acts as a brake on cellular growth.
Now, scientists can quantify that risk by measuring a specific mutation in a tumor-suppressor gene called p53.
The Wilms' tumor-suppressor gene directs the production of a protein whose molecular structure suggests it binds to DNA, either activating or suppressing gene activity.
Finally, evidence is building that problems concerning the tumor-suppressor gene p53 (SN: 5/16/92, p.
For example, several studies of cells sampled from cancer patients' tumors have found that tumor-suppressor genes that normally protect a cell from developing cancer are often silenced by epigenetic modifications.

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