tumor-associated antigen

(redirected from Tumor-associated antigen types)

tu·mor-·as·so·ci·at·ed an·ti·gen

antigens that are highly correlated with certain tumor cells. They are not usually found, or are found to a lesser extent, on normal cells.

tumor-associated antigen

Immunology, oncology A molecule–eg, CA 15.3, 19-9, CA-125, that may be associated with specific tumors–eg, lymphomas, carcinomas, sarcomas, melanomas; TAAs may elicit cellular and/or humoral immune responses against the tumor, but rarely defend the host against the tumor
Tumor-associated antigen types
Class 1 Highly specific for a particular tumor; they are present in one or only a few individuals and not found in normal cells, eg tumor-specific transplantation antigen
Class 2 Present in a number of related tumors from different Pts
Class 3 Present on normal and malignant cells, but are expressed in ↑ amounts in malignant cells  
Note: Class 2 antigens have the  greatest potential for clinically useful assays, as they are present in many tumors and are rarely observed in normal subjects
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