Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients.
Signaling abnormalities apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma.
The presence of tumor-infiltrating lymphocytes has been shown to significantly improve clinical outcomes in many types of cancer.
Studies have shown that the number of tumor-infiltrating lymphocytes in a tumor is correlated with survival in several different types of cancer, including ovarian, (5) pancreatic, (8) skin, (9) and oral (10) cancer.
Results showed that tumor-infiltrating lymphocytes
found in the connective tissue and the tumor itself are predictive of response to platinum-based neoadjuvant chemotherapy and are significantly associated with triple-negative breast cancer subtypes, with the highest frequency in the immunomodulatory subtype.
Prognostic value of tumor-infiltrating lymphocytes
in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.
The response includes (a) peritumoral lymphocytes, defined as lymphocytic aggregates apparent at a scanning magnification, and (b) the presence of tumor-infiltrating lymphocytes, defined as lymphocytes within tumor cell nests or glands (a score of >40 lymphocytes per 10 high-power fields indicates a positive finding).
The morphologic review also focused on evaluating 4 features associated with MSI-H, including lower uterine segment involvement, tumor heterogeneity (dedifferentiation), peritumoral lymphocytes, and >40 tumor-infiltrating lymphocytes per 10 high-power fields.
The young age of presentation, presence of previous history of colorectal carcinoma, positive family history for Lynch syndrome-associated tumors, localization to lower uterine segment, presence of tumor-infiltrating lymphocytes, and synchronous ovarian carcinomas (10,14) should all mandate testing of UEC for DNA MMR genes.
No association was found between age, stage, presence and number of tumor-infiltrating lymphocytes, rhabdoid cell morphology, and clinical outcome.
Predominant Th2/Tc2 polarity of tumor-infiltrating lymphocytes in human cervical cancer.
Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma.