Among RNA-processing proteins, tudor domain containing (TDRD) family proteins are important for germ-cell specific small RNA, piRNA biogenesis (Bak et al., 2011).
TDRD9 contains an ATPase/DExH-box ATPase (DExH)type helicase and a Tudor domain and functions in silencing LINE-1 retrotransposon during spermatogenesis.
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.
Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.