Tubby Protein


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An upstream cell signalling protein common to multicellular eukaryotes which is implicated in mature-onset obesity. It appears to be a transcription factor and possibly also a G-protein-coupled signalling factor. Tubby proteins are involved in neuronal differentiation and development, and when mutated in mammals are linked to obesity, retinal degeneration, and hearing loss
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Because there is evidence that the Tubby protein can interact with G-coupled receptors, including the 5-HT2c (serotonin) receptor (Santagata et al.
1 Rho GTPase-activating protein Head and tail neurons 10 tub-7 Isoform 1 of Tubby protein ASI, ADL, ASK, AWB, ASH, homolog ASJ, PHA and PHB and PDE bbs-1 Isoform 2 of Bardet-Biedl Head and tail neurons and syndrome 1 protein mid-body PDE