felis (3-5,9); Coxiella burnetii (10); Tropheryma whipplei
(11); and Borrelia spp.
Similarly, wholegenome sequence data have identified unique, multicopy, gene targets that increased the sensitivity of molecular diagnostic tests developed for other human pathogens, including Brucella spp, (82) Coxiella burnetii, (83) Tropheryma whipplei
, (84,85) and Neisseria meningitidis.
A+ (8) Rubella A+ (1) SARS (coronavirus) A+ CCHL (1) CHL (1,3,8) Streptococcus ESR pneumoniae CCHL Toxoplasma gondii A+ CHL (1) Trichomonas APATH (1) vaginalis Tropheryma whipplei
A+ Ureaplasma parvum APATH (1) Ureaplasma APATH (1) urealyticum Varicella zoster A+ (VZ) Waikato CCHL CHL (1,2) Whipple's disease (refer Tropheryma whipplei
Additionally A+ (8) Bacterial species Pathogen Sample type Adenovirus Respiratory--nasopharyngeal swab or aspirate, sputum.
, and Coxiella burnetii in environmental samples and blood specimens from febrile patients in Senegal (3-6).
Immunohistochemical tests and polymerase chain reaction tests for 16S ribosomal RNA genes of Tropheryma whipplei
are sensitive methods for the diagnosis of Whipple disease.
endocarditis differs from classic Whipple disease, which primarily affects the gastrointestinal system.
Several studies have assessed the effect of fastidious bacterial infections in systemic febrile illness, including Rickettsia felis (4-6), Coxiella burnetii (7), Tropheryma whipplei
(3), and Borrelia spp.
To the Editor: Tropheryma whipplei
causes Whipple disease, a rare multisystemic disorder that affects mainly middle-aged white men and is most widely distributed in Europe and North America (1).
Screening results from quantitative real-time PCR (qPCR) for Tropheryma whipplei
were negative for blood, saliva, stools, urine, and lymph nodes.
Whipple disease, a rare sporadic disease, was first considered a metabolic disease (1) and later suspected to be an infectious disease caused by a rare bacterium, Tropheryma whipplei
is a bacterium widely known to be associated with Whipple disease (WD), which is characterized by various clinical signs such as diarrhea, weight loss, lymphadenopathy, and polyarthritis (1).
is known mainly as the bacterial pathogen responsible for Whipple disease (1).