Bai, Active fragments-guided drug discovery and design of selective tropane
alkaloids using ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry coupled with virtual calculation and biological evaluation, Anal.
Datura contains tropane
alkaloids such as hyoscine, hyoscyamine and atropine.
alkaloids of Datura innoxia from Morocco," Zeitschrift fur Naturforschung C, vol.
For measuring dopamine synthesis, the most commonly used tracer is [sup.18]F-DOPA, whereas for dopamine transport, several radiolabeled tropane
analogs have been developed.
In addition to contaminants derived from human activities, it is known that honey may become contaminated with natural toxins like alkaloids from various plant species, which is of concern particularly when children consume it; thus, QuEChERS was recently applied to determine both pyrrolizidine and tropane
alkaloids in honey .
Amano et al., "Hyoscyamine 6 beta-hydroxylase, an enzyme involved in tropane
alkaloid biosynthesis, is localized at the pericycle of the root," Journal of Biological Chemistry, vol.
Such seeds contain lysergic acid amide, also known as ergine or LSA, as well as tropane
alkaloids with an anticholinergic effect.
Evolutionary ecology of the tropane
alkaloids of Datura stramonium L.
esters: Detection and mass
KEGG enrichment analysis also revealed that several pathways were specifically affected at the later stage of infection; theseincluded secondarymetabolicpathways suchas"tropane
, piperidineandpyridinealkaloidbiosynthesis,""steroidbiosynthesis," "ABC transporters," "biotin metabolism," "sphingolipid metabolism," "glycosaminoglycan metabolism," "folate biosynthesis," "alpha-linolenic acid metabolism," "regulation of autophagy," "ubiquinone and other terpenoid-quinone biosyntheses," and some "amino acid metabolism" pathways.
Silva et al., "Pervilleine A, a novel tropane
alkaloid that reverses the multidrug-resistance phenotype," Cancer Research, vol.