The culture was positive for pH 6 , it can utilize D-Glactouronic acid, L-Aspartic acid, D-Glucuronic acid, D-Serine and was found sensitive towards Troleandomycin
, Lincomycin, Vancomycin, Rifamycin, Tetrazolium violet, Tetrazolium blue, 1% Sodium lactate, Potassium tellurite and 1% NaCl.
Similar to the effect of statins albeit with some controversy in the literature, some drugs such as some CCBs, erythromycin, troleandomycin
, and ketoconazole inhibit the CYP3A4 enzyme which will reduce the level of the clopidogrel active metabolite which can lead to reduced antiplatelet effect of clopidogrel [68, 73].
A related macrolide antibiotic, troleandomycin
, has been shown to increase quinine exposure in a pharmacokinetic study .
John's Wort Primidone Sulfinpyrazone Weak/moderate Nefazodone Quinidine inhibitors Nevirapine Ranitidine Norfloxacin Sertindole Norfluoxetine Troleandomycin
Omeprazole Verapamil Paroxetine Zafirlukast Propoxyphene Zileuton Strong inhibitors * Ketoconazole Ritonavir Nelfinavir Saquinavir * Requires dosage modification when used in combination with PDE5 inhibitor.
It should not be used within at least 72 hours of treatment with ketoconazole, itraconazole, nefazodone, troleandomycin
, clarithromycin, ritonavir, and nelfinavir.
Contraindicated in patients with hepatic dysfunction, and in those who are taking mibefradil, erythromycin, clarithromycin, troleandomycin
, quinine, ketoconazole, or itraconazole.
Other macrolide antibiotics include dirithromycin and troleandomycin
, which are not used extensively in children, and tacrolimus, which is used in solid organ transplantation as an immunosuppressant.
Of particular interest for dangerous interactions are enoxacin, fluvoxamine, mexiletine, propanolol, and troleandomycin
. These drugs interfere with the cytochrome P450 metabolism of theophylline and increase the elimination half-life, thus increasing the theophylline blood concentration.
(17) The CYP3A inhibitors included in the analysis were nitroimidazole antifungal agents, diltiazem, verapamil, and troleandomycin
. These studies suggest that simultaneous use of erythromycin and inhibitors of cytochrome P450 3A4 enzymes should be avoided.
Drug Reference Erythromycin and troleandomycin
 Cyclosporine  FK506  Lidocaine  Nifedipine  Tamoxifen  Others 
Drug Interactions * Troleandomycin
can cause increased steroid blood levels.
itraconazole, miconazole, troleandomycin