Background: Triptolide, an active ingredient extracted from the Chinese herb Tripterygium wilfordii
According to the world's folk and traditional medicine some plants including Gossypium herbaceum (5), Azadirachta indica (6-7), Tripterygium wilfordii
(8), Echiveria gibbiflora (9-10), Allium sativum (11), Carica papaya (12), Alstonia macrophylla (13), Ricinus communis (14), Achyranthes aspera and Stephania hernandifolia (15) have been tested for their male contraceptive effects.
Comparison of Tripterygium wilfordii
Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial.
Triptolide, the active ingredient purified from the plant Tripterygium wilfordii
Hook F, has been shown in animal models to be effective against cancer, arthritis and skin graft rejection.
today announced the publication of the results of a 6 month, Phase 2b clinical trial with an extract of Tripterygium wilfordii
Hook F (TwHF) to be developed as PMI-001, in patients with rheumatoid arthritis, in the August 18, 2009 issue of the Annals of Internal Medicine.
Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii
root extracts of Tripterygium wilfordii
by solid-phase extraction and
It has anti-inflammatory and immunosuppressive properties, and its toxicity is being assessed in NIH studies of extracted cells from Tripterygium wilfordii
grown in the laboratory.
8] In Southern China, an herb, tripterygium wilfordii
hook-F, is used to suppress the immune response and thus the disease.
Triptolide is the principle active component of the traditional Chinese medical plant called Tripterygium wilfordii
Effects of triptolide from Tripterygium wilfordii
on ERalpha and p53 expression in two human breast cancer cell lines.
Selected examples include Tripterygium wilfordii
(thunder God vine), Camellia sinensis (green tea), Uncaria tomentosa (cat's claw), and Zingiber officinale (ginger).