randomized controlled trial

(redirected from Triple-blind)

ran·dom·i·zed con·trolled tri·al (RCT),

an epidemiologic experiment in which subjects in a population are allocated randomly into groups, called "experimental" or "study" and "control" groups to receive or not receive an experimental therapeutic or preventive regimen, procedure, maneuver, or intervention.
Farlex Partner Medical Dictionary © Farlex 2012

ran·dom·i·zed con·trolled tri·al

(RCT) (ran'dŏm-īzd kŏn-trōld trī'ăl)
A type of experiment that randomly assigns subjects to various interventions, including a control group, in order to minimize the risk of bias.
See also: control group
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

randomized controlled trial

Abbreviation: RCT
An experimental study to assess the effects of a particular variable, e.g., a drug or treatment, in which subjects are assigned randomly to an experimental, placebo, or control group. The experimental group receives the drug or procedure; the placebo group's medication is disguised to resemble the drug being investigated. The control group receives nothing. Members of each group are prevented from knowing whether they are receiving active therapy. The researchers gathering the data are also typically blinded to group assignment.


Although RCTs are an essential element in proving clinical relationships (such as between the use of a new drug and the safe cure of a disease), most RCTs do not enroll enough patients for a long enough time to detect rare events.
See also: trial
Medical Dictionary, © 2009 Farlex and Partners

trial, randomized controlled (RCT) 

An experimental design used for testing the effectiveness of a new medication or a new therapeutic procedure. Individuals are assigned randomly to a treatment group (experimental therapy) and a control group (placebo or standard therapy) and the outcomes are compared. The trial is strengthened by 'blinding' or masking (single-blind, double-blind or triple-blind study) and cross-over design. RCT is the most accepted scientific method of determining the benefit of a drug or a therapeutic procedure. It represents the best evidence available, which is integrated into the final decision about the management of a condition by healthcare practitioners in what is called evidence-based healthcare. Syn. randomized clinical trial. See sampling; significance; study.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann
References in periodicals archive ?
(10) The most important study of that year, however, was a randomized, triple-blind, placebo-controlled trial (n= 40 non-smoking healthy young adults, mean age 20 years).
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The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial.
That's why it's recommended to implement any physical hardware with triple-blind encryption while making sure the resident portal app is equipped with payment-level security.
(50) In a randomized, triple-blind, placebo-controlled, crossover study of 35 patients, a menthol 10% solution was shown to be more efficacious as abortive treatment of migraine headaches than placebo.
which strictly adhered to triple-blind protocols) were included.
In a triple-blind, placebo-controlled, randomized, pre- and post-intervention assessment design, 20 healthy participants without current mood disorder received a 4-week probiotic food-supplement intervention with the multispecies probiotics, while 20 control participants received an inert placebo for the same period.
Belief can be so strong that pharmaceutical companies use double- and triple-blind randomized studies to try to exclude the power of the mind over the body when evaluating new drugs.
This triple-blind randomized placebo-controlled crossover trial evaluates the acute effect of topical menthol (Biofreeze) and placebo (gel with a menthol scent) on chronic pain in Danish slaughterhouse workers with symptoms of carpal tunnel syndrome.