Trinucleotide Repeat Disorder

(redirected from Trinucleotide Repeat Expansion Disorder)
A class of clinically heterogenous disorders, defined by the presence of an abnormal and unstable expansion of DNA—triplet repeats—in the mutant gene, with up to 200 copies of the repeated trinucleotide
Examples Hereditary—CAG repeats (Huntington’s disease, Kennedy’s disease), CGG (fragile X syndrome), GCT (myotonic dystrophy, spinal and bulbar muscle atrophy); Acquired—some forms of colourectal CA
References in periodicals archive ?
They discuss biogenesis and applications of microRNA; non-canonical microRNA biogenesis and function; non-coding RNAs and the epigenetic control of gene expression; the clinical translation of microRNA technologies for somatic cell reprogramming; systems biology tools for understanding the role of host microRNAs in infection, particularly in HIV; synthetic microRNA blocking agents; using microRNAs to regulate transgene expression, for gene silencing, and using RNAi for the treatment of viral infections; the role of microRNAs in cancers associated with human tumor viruses; microRNAs as cancer biomarkers; and microRNA deregulation in trinucleotide repeat expansion disorders.