organotin

(redirected from Trimethyltin chloride)
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organotin

Any tin-based organic compound in wide use for marine anti-fouling paints, wood catalysts, plasticisers, slimicides, in industrial water systems and as fungicides. Human exposure results from contaminated seafood, agricultural products and drinking water. Blood levels of organotins may be high enough to act on retinoid X receptors and PPAR gamma, upregulating the adipogenic signalling pathway, which explains organotins’ obesogenic effects.
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Yoneda, "Regeneration of granule neurons after lesioning of hippocampal dentate gyrus: evaluation using adult mice treated with trimethyltin chloride as a model," Journal of Neuroscience Research, vol.
Zheng et al., "Trimethyltin chloride (TMT) neurobehavioral toxicity in embryonic zebrafish," Neurotoxicology and Teratology, vol.
Blockade of glutamatergic and GABAergic receptor channels by trimethyltin chloride. British Journal of Pharmacology 144, 283-292.