organotin

(redirected from Trimethyltin chloride)
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organotin

Any tin-based organic compound in wide use for marine anti-fouling paints, wood catalysts, plasticisers, slimicides, in industrial water systems and as fungicides. Human exposure results from contaminated seafood, agricultural products and drinking water. Blood levels of organotins may be high enough to act on retinoid X receptors and PPAR gamma, upregulating the adipogenic signalling pathway, which explains organotins’ obesogenic effects.
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Abbreviations TMT: Trimethyltin chloride LBP: Lycium barbarum polysaccharides Shh: Sonic Hedgehog GSK-3[beta]: Glycogen synthase kinase-3[beta] N2a: Neuro-2a ROS: Reactive oxygen species MDA: Malondialdehyde SOD: Superoxide dismutase PD: Parkinson's disease AD: Alzheimer's disease DMEM: Dulbecco's modified Eagle's medium MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide DCFH-DA: 2,7-Dichlorofluorescein diacetate FBS: Fetal bovine serum DMSO: Dimethyl sulfoxide TBA: Thiobarbituric acid.
Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-[kappa]B and MAPKs signaling pathways," Archives of Toxicology, vol.
Blockade of glutamatergic and GABAergic receptor channels by trimethyltin chloride.