They found that people who ate red meat as their main source of protein for 1 month had levels of trimethylamine N-oxide
(TMAO) that were two to three times higher than those in people who got their protein primarily from white meat or non-meat sources.
A new research at the Medical University of Warsaw found that low-dose treatment with trimethylamine N-oxide
(TMAO) reduced heart thickening (cardiac fibrosis) and markers of heart failure in an animal model of hypertension.
Intake of fish, seafood and vegetarian food increases levels of a compound called trimethylamine N-oxide
(TMAO), known to boost heart health, said researchers from the Medical University of Warsaw in Poland,reported health news.
At Cleveland Clinic, nontraditional biomarkers in routine use include high-sensitivity C-reactive protein (hsCRP), lipoprotein(a), homocysteine, trimethylamine N-oxide
(TMAO), myeloperoxidase and N-terminal pro-brain natriuretic peptide (NT-proBNP).
TMA is then oxidized to trimethylamine N-oxide
(TMAO), a potent vascular oxidant linked to significant atherosclerosis.
In this review, we aimed to discuss the compositional and functional changes in the gut microbiota in relation to CVD, determine the effects of the gut microbiota on CVD from the view of trimethylamine N-oxide
(TMAO) and immune cells, and evaluate how gut interventions can lead to novel therapeutic targets for CVD.
TMA is absorbed and transmitted to the liver, where it can be rapidly detoxified by monooxygenase 3 (FMO3) to be transformed into trimethylamine N-oxide
(TMAO) is a plasma metabolite from nutrient precursors (choline, phosphatidylcholine, and L-carnitine), which is produced by gut microbiota.
The results showed that aspartate, betaine, choline, cysteine, ethanol, and threonine were increased over 2-fold in the muscle; propionate and trimethylamine were increased over 2-fold in the plasma; and alanine, glycerol, inosine, lactate, and pyruvate were increased over 2-fold and acetoacetate, arginine, citrulline, creatine, glutamine, glutarate, hippurate, lysine, methionine, phenylacetylglycine, taurine, trigonelline, trimethylamine, and trimethylamine N-oxide
were decreased below 0.5-fold in the urine (Figure 1).
 investigated the effects of gut microbial-dependent trimethylamine N-oxide
(TMAO) in patients with CKD.
The investigators measured levels of trimethylamine N-oxide
(TMAO)--a compound formed when bacteria in the digestive tract break down dietary nutrients found in red meat, eggs, and meat products--in 935 PAD patients.