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A drug combination consisting of a dihydrofolate reductase inhibitor (trimethoprim) and a sulfonamide antibacterial drug (sulfamethoxazole). The drug combination is synergistic as the drugs interfere with two successive steps in the formation/utilization of folic acid by microorganisms. Used to treat many infectious diseases.
trimethoprim-sulfamethoxazoleBactrim®, Septra® A broad-spectrum combination antibacterial, formulated as a 1:20 ratio of T to S, which is effective in genitourinary, GI, and respiratory tract infections; it is the antibiotic of choice in PCP for which the failure rate of 5-20%; T-S is also effective against Salmonella, Shigella, Nocardia spp, H influenzae, Listeria monocytogenes, S pneumoniae, Isospora belli, and possibly Toxoplasma gondii; T-S is non-toxic in non-immunocompromised Pts; up to 60% of AIDS Pts have adverse effects–eg, ↑ LFTs, neutropenia, thrombocytopenia, erythematous maculo-papular rash, Stevens-Johnson syndrome, exfoliative dermatitis, N&V
An antibiotic used to treat and prevent PCP.
Mentioned in: Pneumocystis Pneumonia
tri·meth·o·prim-sul·fa·meth·ox·a·zole(TMP/SMX) (trī-meth'ō-prim sŭl'fă-meth-oks'ă-zōl)
Drug combination consisting of a dihydrofolate reductase inhibitor and a sulfonamide antibacterial drug; drug combination is synergistic as the drugs interfere with two successive steps in formation/use of folic acid by microorganisms. Used to treat many infectious diseases.