) is the current mainstay of treatment for Cushing's --both PDH and ADH.
Mitotane, selegiline, and trilostane
are the drugs used.
is the drug most commonly used by veterinarians to help with Cushing's disease treatment in cats.
In a study on 3[beta]-HSD enzyme activity of the porcine corpus luteum, in vitro treatment of cultured luteal cells with T3 showed a marked increase in progesterone concentrations, measured via radioimmunoassay, against trilostane
, a competitive inhibitor 3[beta]-HSD.
Among the 20 dogs with HAC, 19 dogs were treated with trilostane
(1.5-2.5mg/kg, q 12 hours) and one dog was treated with ketoconazole (12 mg/kg, q 12 hours) for the condition of PDH.
Mitotane, Ketoconazole and Trilostane
are three treatments commonly used in management of PDH in dogs (Boari and Aste, 2003).
Inhibition of progesterone secretion with trilostane
for mid-trimester termination of pregnancy: randomized controlled trials.
Adrenal necrosis in a dog receiving trilostane
for the treatment of hyperadrenocorticism.
Dechra Veterinary Products promotes and sells Vetoryl[R] (trilostane
), Felimazole[R] (methimazole) and high quality veterinary approved dermatologic and ophthalmic products to veterinarians.
The treatment of choice is Vetoryl (trilostane
), available in capsules, and it is safe and effective.
The agents inhibiting steroidogenesis include: metyrapone, ketoconazole, mitotane, aminoglutethimide, trilostane
OVX/ADX rats treated with 17-beta-estradiol benzoate (EB) were given trilostane
, aminoglutethimide, RU486, or aCSF and tested 48 h after EB treatment for reproductive behaviors.