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an anticonvulsant used in the treatment of partial seizures, administered orally.


Apo-Oxcarbazepine (CA), Trileptal

Pharmacologic class: Carboxamide derivative

Therapeutic class: Anticonvulsant

Pregnancy risk category C


Blocks sodium channels in neural membranes, stabilizing hyperexcitable states and inhibiting neuronal firing and impulse transmission in brain


Oral suspension: 300 mg/5-ml bottle

Tablets: 150 mg, 300 mg, 600 mg

Indications and dosages

Adjunctive therapy for partial seizures

Adults: 300 mg P.O. b.i.d. May increase by up to 600 mg/day q week, to a maximum of 1,200 mg/day.

Children ages 2 to 16: Initially, 8 to 10 mg/kg/day P.O. to a maximum of 600 mg/day

Conversion to monotherapy for partial seizures

Adults: 300 mg P.O. b.i.d. May increase by 600 mg/day at weekly intervals over 2 to 4 weeks, to a maximum of 2,400 mg/day

Children ages 4 to 16: Initially, 8 to 10 mg/kg/day P.O. given in two divided doses, increased to a maximum of 10 mg/kg/day

Initiation of monotherapy

Adults: 300 mg P.O. b.i.d., increased by 300 mg/day P.O. q 3 days up to 1,200 mg/day

Children ages 4 to 16: Initially, 8 to 10 mg/kg/day P.O. given in two divided doses; increase by 5 mg/kg q 3 days to a maximum of 1,200 mg/day

Dosage adjustment

• Renal impairment
• Children ages 2 to younger than 4 weighing less than 20 kg (44 lb)


• Hypersensitivity to drug or its components


Use cautiously in:
• renal impairment
• pregnant or breastfeeding patients
• children younger than age 2 (safety not established).


• Administer twice daily with or without food.
• Shake oral suspension well. If desired, mix in small glass of water.

Adverse reactions

CNS: dizziness, vertigo, drowsiness, fatigue, headache, ataxia, tremor, emotional lability

EENT: abnormal vision, diplopia, nystagmus, rhinitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia

Metabolic: hyponatremia

Skin: acne, rash

Other: thirst, allergic reactions, edema, lymphadenopathy


Drug-drug.Carbamazepine, valproic acid, verapamil: decreased oxcarbazepine blood level

CNS depressants (including antidepressants, antihistamines, opioids, sedative-hypnotics): additive CNS depression

Felodipine, hormonal contraceptives: decreased blood levels of these drugs

Phenobarbital: decreased oxcarbazepine and increased phenobarbital blood levels

Phenytoin: increased phenytoin blood level

Drug-diagnostic tests.Sodium: decreased level

Drug-behaviors.Alcohol use: additive CNS depression

Patient monitoring

• Monitor neurologic status closely for changes in cognition, mood, wakefulness, balance, and gait.
• Check sodium level. Watch for signs and symptoms of hyponatremia.

Patient teaching

• Instruct patient to take at same time each day, with or without food.
• Tell patient to report vision changes and significant neurologic changes.
• Advise patient to have periodic eye exams.
• Tell female patient that drug makes hormonal contraceptives less effective.
• Inform patient that he may need frequent tests to check drug blood levels.
• Tell patient not to drink alcohol.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects him.
• As appropriate, review all significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.


/ox·car·baz·e·pine/ (oks″kahr-baz´ĕ-pēn) an anticonvulsant used in the treatment of partial seizures.


an anticonvulsant used in the treatment of partial seizures. It is administered orally.
References in periodicals archive ?
UCB's Vimpat, on the market for just over three years, captures 8 percent patient share -- on par with more established AEDs, such as Novartis' Trileptal, UCB's Keppra XR and Abbott's Depakote.
26 billion, despite generic competition to blood pressure pill Lotrel and epilepsy medication Trileptal.
The patents of leading anticonvulsants such as Topamax (topiramate), Trileptal (oxcarbazepine), Depakote (divalproex sodium), Keppra (levetiracetam), Lamictal (lamotrigine) and Tegretol (carbamazepine) expired in 2007-2008.
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He took me off of Zoloft and eventually put me on Trileptal, because the Zoloft just made me want to sleep and eat.
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To mediate the pain, I upped my intake of Trileptal, returning to around 600 mg/day.