tricyclic antidepressant

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Related to Tricyclics: Heterocyclics, MAOIs

tri·cyc·lic an·ti·de·pres·sant

a chemical group of antidepressant drugs that share a three-ringed nucleus.
Farlex Partner Medical Dictionary © Farlex 2012

tricyclic antidepressant

n. Abbr. TCA
Any of a group of antidepressant drugs, such as amitryptyline, that contain three fused benzene rings and that block the reuptake of the neurotransmitters norepinephrine and serotonin in the central nervous system.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

tricyclic antidepressant

Pharmacology Any psychoactive dibenzozepine derivative–eg, which have 3 central rings and a short linear chain attached to the terminal nitrogen and are thus tertiary amines Lab TA levels correlate poorly with the clinical status, as circulating levels of the highly lipid-soluble TCA represent a minute portion of the body load, and TCA metabolites with similar clinical effects may not be measured Clinical, overdose Parasympathetic disease with anticholinergic effects–eg, mydriasis, xerostomia, urinary retention, ↓ peristalsis, cardiac disease–intractable myocardial depression, hypotension, ventricular tachycardia, fibrillation, or heart block and CNS disease–confusion, agitation, hallucinations, myoclonus, seizures, lethargy that may progress to coma and respiratory arrest Adverse effects Dry mouth, constipation, blurred vision, hyperthermia, weakness, fatigue, lethargy, insomnia, confusion, seizures, ↓ peristalsis, hypotension, coma. See Desipramine, Imipramine, Nortriptyline, Therapeutic drug monitoring, Tricyclic antidepressant suicide. Cf Fluoxetine, Monoamine oxidase inhibitors.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressant drugs that share a three-ringed nucleus.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressants that share three-ringed nucleus.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
In descending order, the remaining odds ratios were 2.0 for citalopram, 1.5 for tricyclic antidepressants, 1.4 for sertraline, and 1.3 for escitalopram, but only the odds ratio for citalopram reached statistical significance (95% Cl, 1.3-2.9; P = .001).
Tricyclic antidepressants block the reuptake of serotonin and norepinephrine, are competitive inhibitors of [H.sub.1] and [H.sub.2] histamine receptors, have anticholinergic effects, and have quinidinelike effects on cell membranes.
The pooled results from 8 RCTs with 517 patients (72% female, mean age 40) demonstrated greater improvement of abdominal pain with tricyclic and selective serotonin reuptake inhibitor antidepressants than placebo over 6 to 12 weeks (54% vs 37%; RR=1.5; 95% CI, 1.1-2.1; NNT=5).
About a third of the subjects who had been prescribed a drug received a tricyclic antidepressant.
Analysis showed people taking tricyclic anti-depressants had a much lower risk of glioma and lower risk of bowel cancer.
According to data gathered from the Scottish Health Survey, people who take a class of older antidepressants known as tricyclic antidepressants have an increased risk of heart disease.
They compared outcomes between 40 treated with low-dose tricyclic antidepressants and 56 given education on coping strategies and reassurance only.
According to psychiatrist Dr Prem Misra, he has probably swallowed an older type of drug called tricyclic anti- depressants, as they produce the kind of symptoms described.
Like the tricyclic antidepressants (TCAs), which are first-line treatment for many chronic pain states, milnacipran has a preference for norepinephrine over serotonin.