Trichuris suis (pig whipworm), for example, suppresses TLR4-induced inflammatory responses in human macrophages, according to M.
The helminth Trichuris suis suppresses TLR4-induced inflammatory responses in human macrophages [abstract].
Washington, June 21 ( ANI ): A team consisting of 11 institutions from six countries, including BGI, presented the whole-genome sequence of Trichuris suis
, a parasitic worm in pig.
The researchers found an innocuous gut parasite, the pig whipworm Trichuris suis, that didn't cause disease in people.
Live eggs (right) from the parasitic pig whipworm, Trichuris suis, can quell inflammation in people with ulcerative colitis.
In a pilot study of 29 adult patients with longstanding, refractory Crohn's disease, patients were given a drink containing 2,500 specially prepared ova of Trichuris suis
, the pig whipworm, every 3 weeks for 24 weeks.
We compliment Kradin et al (1) for their interesting article "Iatrogenic Trichuris suis
Infection in a Patient With Crohn Disease.
Swallowing the ova of the pig whipworm, Trichuris suis
, results in brief, self-limited colonization in humans without causing disease.
Francois-Xavier Frapaise MD, CEO and President of Asphelia, will introduce Asphelia's core-assets - namely, a trichuris suis
ova-based therapy (ASP 1002) and an oral integrin antagonist (ASP 2002).
A similar approach using eggs from another parasitic worm, Trichuris suis
, is currently being tested in clinical trials in patients with Crohn's disease and multiple sclerosis.
23), (24) However, "worm therapy" using the helminth Trichuris suis
has been reported to significantly improve IBD symptoms.
In one open-label study, 29 patients with active Crohn's disease took 2,500 Trichuris suis
(pig whipworm) ova every 3 weeks for 24 weeks (Gut 2005;54:87-90).