USP47

(redirected from Trf (TATA binding protein-related factor)-proximal homolog)

USP47

A gene on chromosome 11p15.3 that encodes a deubiquitinase of the C19 peptidase family which acts on monoubiquitinated DNA polymerase beta (POLB), stabilising it and thereby playing a role in base-excision repair. USP47 regulates cell growth and genome integrity and may indirectly regulate CDC25A expression at a transcriptional level.