Syphilis a sexually transmitted infection is caused by the spirochete
Treponema pallidum subsp. pallidum. The disease is chronic and progresses through distinct clinical stages and diverse clinical manifestations making laboratory testing a very important aspect for detecting syphilis.
Giacani, "
Treponema pallidum subsp. pallidum TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end," PLoS Neglected Tropical Diseases, vol.
The presence of clinical signs or medical history with direct detection of the bacterium
Treponema pallidum subsp. pallidum in clinical specimens and/or reactive treponemal and non-treponemal tests is required to diagnose syphilis (1, 2).