Syphilis a sexually transmitted infection is caused by the spirochete Treponema pallidum subsp. pallidum
. The disease is chronic and progresses through distinct clinical stages and diverse clinical manifestations making laboratory testing a very important aspect for detecting syphilis.
Giacani, "Treponema pallidum subsp. pallidum
TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end," PLoS Neglected Tropical Diseases, vol.
The presence of clinical signs or medical history with direct detection of the bacterium Treponema pallidum subsp. pallidum
in clinical specimens and/or reactive treponemal and non-treponemal tests is required to diagnose syphilis (1, 2).