Tree Man Disease

An extremely rare autosomal recessive [MIM 226400] hereditary skin disorder associated with a high risk of skin cancer, characterised by marked susceptibility to HPV (type 5, 8) infection, which in the normal population is asymptomatic, but in these patients gives rise to scaly maculopapular lesions of the hands and feet, which have been fancifully likened to tree bark
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'Tree Man Disease' is caused by a defect in the immune system.