traumatic axonal injury

traumatic axonal injury

A post-traumatic form of diffuse brain injury which affects the white matter, and is divided into three grades by histology.

Traumatic axonal injury
Grade 1: Abnormalities are identified by histology only.
Grade 2: Widely distributed axonal damage, plus focal lesion in the corpus callosum.
Grade 3: Diffuse axonal damage, plus focal lesions in the corpus callosum and the brainstem.

Diagnosis
Immunocytochemistry for amyloid precursor protein A-beta-PP, which can be identified in all patients who survive 3+ hours after traumatic head injury. A-beta-PP can also be seen in infarction, hypoglycaemia, and HIV infection. Long-standing lesions can be identified by CD68, a marker of microglial activation.
References in periodicals archive ?
One-year follow-up of patients after traumatic axonal injury has shown that fatigued patients had subjective experience of significantly higher cognitive dysfunction and a lower quality of life than shown on the application scales [12].
[5,6] Among these in particular is diffusion tensor imaging (DTI); traumatic axonal injury which is characterised by a reduction in fractional anisotrophy (FA) on DTI.
found that injecting MDL28170 before TBI alleviated traumatic axonal injury, which proved potential efficacy of MDL28170 for TBI.[sup][51] Ai et al .
Izzy et al., "Longitudinal Diffusion Tensor Imaging Detects Recovery of Fractional Anisotropy Within Traumatic Axonal Injury Lesions," Neurocritical Care, vol.
In addition, traumatic axonal injury has been shown to lead to selective atrophy in a regional manner similar to what is observed following focal injury [32].
Povlishock, "Traumatic axonal injury in the perisomatic domain triggers ultrarapid secondary axotomy and Wallerian degeneration," Experimental Neurology, vol.
Mills, "Internal jugular vein compression mitigates traumatic axonal injury in a rat model by reducing the intracranial slosh effect," Neurosurgery, vol.
Data reported at the annual meeting of the American Academy of Neurology show that 43% of a cohort of 40 symptomatic NFL retirees had abnormal results on diffusion tensor MRI and 30% had evidence of traumatic axonal injury on conventional MRI.
Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model.
Executive functions rely upon network interactions between several cortical, subcortical, and cerebellar brain regions [16, 41, 42], leaving them vulnerable to traumatic axonal injury (TAI) as a consequence of TBI [43-45].
In cases of severe injury, traumatic axonal injury may be present resulting in disconnection and significant disruption of axonal transport (Barkhoudarian, Hovda, & Giza, 2011).

Full browser ?