buprenorphine hydrochloride

(redirected from Transtec)

buprenorphine hydrochloride

Buprenex, Burinex (UK), Subutex, Temgesic (UK), Transtec (UK)

Pharmacologic class: Opioid agonist-antagonist

Therapeutic class: Opioid analgesic

Controlled substance schedule III

Pregnancy risk category C


Unclear. May bind to opiate receptors in CNS, altering perception of and response to painful stimuli while causing generalized CNS depression. Also has partial antagonist properties, which may lead to opioid withdrawal effects in patients with physical drug dependence.


Injection: 300 mcg (0.3 mg)/ml

Tablets (sublingual): 2 mg, 8 mg

Indications and dosages

Moderate to severe pain

Adults: 0.3 mg I.M. or slow I.V. q 6 hours as needed. Repeat initial dose after 30 to 60 minutes.

Children ages 2 to 12: 2 to 6 mcg (0.002 to 0.006 mg)/kg I.M. or slow I.V. q 4 to 6 hours

Opioid dependence

Adults: 12 to 16 mg/day S.L.

Dosage adjustment

• Elderly patients


• Hypersensitivity to drug
• Elderly patients
• MAO inhibitor use within 14 days


Use cautiously in:
• increased intracranial pressure (ICP); respiratory impairment; severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; undiagnosed abdominal pain; prostatic hypertrophy; systemic lupus erythematosus; gout; kyphoscoliosis; diabetes mellitus; alcoholism
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 13.


• Mix with lactated Ringer's injection, dextrose 5% in water, or normal saline solution.

Give I.V. dose slowly over no less than 2 minutes. Drug may cause respiratory depression (especially initial dose).
• When giving I.M., rotate injection sites to prevent induration and abscess.
• If patient is immobilized, reposition him frequently and keep head of bed elevated.

Adverse reactions

CNS: confusion, malaise, hallucinations, dizziness, euphoria, headache, unusual dreams, psychosis, slurred speech, paresthesia, depression, tremor, agitation, seizures, coma, increased ICP

CV: hypertension, hypotension, palpitations, tachycardia, Wenckebach (Mobitz Type 1) block, bradycardia

EENT: blurred vision, diplopia, amblyopia, miosis, conjunctivitis, tinnitus

GI: nausea, vomiting, constipation, flatulence, ileus, dry mouth

GU: urinary retention

Respiratory: hypoventilation, dyspnea, cyanosis, apnea, respiratory depression

Skin: diaphoresis, pruritus

Other: physical or psychological drug dependence, drug tolerance


Drug-drug.Antidepressants, antihistamines, sedative-hypnotics: additive CNS depression

MAO inhibitors: increased CNS and respiratory depression, increased hypotension

Drug-herbs.Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• Check hepatic function before and during therapy.
• Monitor respiratory status throughout therapy. Respiratory rate of 12 breaths/minute or less may warrant withholding dose or decreasing dosage.

Patient teaching

• Instruct patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from sudden blood pressure drop.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Advise patient to increase daily fluid intake to help prevent constipation.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

Mentioned in ?
References in periodicals archive ?
Transtec has signed a four-year (2014-2018) service contract with the European Training Foundation (ETF) based in Turin, Italy for the provision of (1) expertise in:
Pavement engineer Transtec Group has released Command Center 2.
The vehicles, which were showcased at Saudi Transtec 2015, are available with the manufacturer's 'Hot Climate Package', which has been developed specifically for GCC countries.
gov or 708-283-3533, or David Merritt at The Transtec Group at dmerritt@thetranstecgroup.
JEDDAH: ARAB NEWSSaudi Transtec 2013, now in its fourth edition, will take place in Dammam from Dec.
THE recently held third Saudi Transtec in Dhahran provided a strong platform for players in the transport and logistics sectors to discuss current developments and future opportunities.
International and regional logistics leaders came together yesterday in Riyadh to share industry developments and discuss future opportunities at the third Saudi Transtec Exhibition & Conference in Dammam.
transtec Computers Ltd, a UK-based subsidiary of transtec AG, said yesterday that it is now offering its customers IT solutions with the new Intel processor architecture, codename Sandy Bridge.
Sponsored by Aramex, the global logistics and transportation solutions provider, Saudi Transtec 2010 is a three-day event that brings together stakeholders from across the industry, including participants from major government and private-sector firms.
Richard Carr, of Snitterfield Road, Bearley, Warwickshire, was barred from the Institute of Chartered Accountants for misconduct of "a serious and sustained nature" while at TransTec.
European manufacturers ETegro Technologies, MAXDATA and Transtec along with R Cubed Technologies in the United States will sell notebooks and/or desktop computers with SUSE Linux Enterprise Desktop 10 already installed, giving customers around the world simplified access to a complete desktop computing solution that dramatically reduces costs, improves end-user security and increases workforce productivity.
William Jeffrey, the former group finance director of city-based TransTec, was sentenced to nine months in prison, suspended for a year, at Birmingham Crown Court yesterday by Judge Derek Stanley.