ATUM has discovered, characterized and patented two new families of transposases
The primary structures of the pseudogenes derived proteins showed very high sequence identity (<83%) with other bacterial enzymes such as aldolases, synthase, and transposases
(Table S1), suggesting that these genes can produce active proteins if transcribe.
The presence of IS26, ISCR1, and transposases
have been increasingly implicated in interspecies and intraspecies dissemination of antimicrobial drag resistance genes (35,36).
An increased capacity for horizontal gene transfer appears to be consistent with harsh environmental conditions; microbial taxa often show enrichment of genes such as integrases or transposases
that are involved in genetic recombination events, enabling species to cope with and adapt to extreme or competitive habitats such as hydrothermal vents (Tang et al.
The most representative signatures include G + C content, dinucleotide biases, codon usage, mobility genes (including transposases
and integrases), and tRNA genes [14, 15].
This is achieved by optimizing the enzymatic reactions to allow multiple steps to be run simultaneously while avoiding bias that is inherent with enzymatic fragmentation and transposases
Topics include: transposon Tn7, mercury resistant transposons, integrons, inteins and introns, restriction-modification systems as mobile epigenetic elements, Tn1549 and closely related elements, integrative and conjugative elements encoding DDE transposases
, and the staphylococcal cassette chromosome.
DNA-binding specificity of rice mariner-like transposases
and interactions with Stowaway MITEs.
, integrases and resolvases/invertases belong to the group of recombinases.
Scientists studying VDJ recombination noticed that flanking each V, D, and J gene segment were brief DNA sequences that resemble those on which transposases
they lack transposases
, insertion elements, or genes encoding DNA modification enzymes).
Generally, pO113 exhibited a mosaic structure similar to pO157, encoding a large number of transposases
and insertion elements clustered outside a plasmid transfer region.