The transmembrane proteins
are very important as they play different roles in life activities of cells therefore knowledge about membrane buried residues in transmembrane proteins
is of great importance .
Occludin is a transmembrane protein
that is capable of linking with ZO-1.
The huge local dielectric permittivity of the transmembrane proteins
and their clusters (rafts), are active in the electro-orientation of cells .
1993 Transcriptional induction of genes encoding endo plasmic reticulum resident proteins requires a transmembrane protein
After RANKL binds to RANK, a key preliminary step in downstream signaling is binding of TRAFs to specific sites within the cytoplasmic domain of RANK, which is a transmembrane protein
that--like the TNF receptors - has no intrinsic ability to activate protein kinases to mediate signaling.
MARCH6 was first identified as a TEB4, a mammalian ortholog of the yeast transmembrane protein
Doa10, an E3 ligase located in the membrane of the ER and nuclear envelope that is implicated in endoplasmic reticulum-associated degradation (ERAD) [40, 41].
7] Human genes: RET, ret proto-oncogene; VHL, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; NF1, neurofibromin 1; SDHD, succinate dehydrogenase complex, subunit D, integral membrane protein; TMEM127, transmembrane protein
127; MAX, MYC associated factor X.
The Keck School investigators found that interferon-inducible transmembrane protein
3 (IFITM3) can disrupt the interaction between Vesicle-membrane-associated protein (VAPA) and oxysterol-binding protein (OSBP) that regulates the transport and stability of cholesterol, which are required for many viruses to take hold.
This gene encodes capillary morphogenesis protein 2(CMG2), a transmembrane protein
that is induced during capillary morpho- genesis.
67 2 (beta-1,6-N-acetylglucosaminyltransferase) TMEM86A transmembrane protein
EPCR is not only a 46-kDa endothelial cell-specific type-I transmembrane protein
, it also has a soluble form circulating in plasma (5), (6).
X- linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein