domain

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do·main

(dō-mān'),
1. Homologous unit of approximately 110-120 amino acids, groups of which make up the light and heavy chains of the immunoglobulin molecule; each serves a specific function. The light chain has two domains, one in the variable region and one in the constant region of the chain; the heavy chain has four to five domains, depending on the class of immunoglobulin, one in the variable region and the remaining ones in the constant region.
2. A region of a protein having some distinctive physical feature or role.
3. An independently folded, globular structure composed of one section of a polypeptide chain. A domain may interact with another domain; it may be associated with a particular function. Domains can vary in size.
[Fr. domaine, fr. L. dominium, property, dominion]

domain

/do·main/ (do-mān´) in immunology, any of the homology regions of heavy or light polypeptide chains of immunoglobulins.

domain

(dō-mān′)
n.
Biology Any of three primary divisions of organisms, consisting of the eukaryotes, bacteria, and archaea, that rank above a kingdom in taxonomic systems based on similarities of DNA sequences.

domain

a region of a protein or polypeptide whose three-dimensional configuration enables it to interact specifically with particular receptors, enzymes, or other proteins.

domain

EBM
Any of a collection of observations with a topic-specific commonality about each subject in a clinical trial, which the Clinical Data Interchange Standards Consortium (CDISC) divides into different classes:
• Interventions class;
• Events class;
• Findings class.

do·main

(dō-mān')
1. Homologous unit of 110-120 amino acids, groups of which make up the light and heavy chains of the immunoglobulin molecule; each serves a specific function. The light chain has two domains, one in the variable region and one in the constant region of the chain; the heavy chain has four to five domains, depending on the class of immunoglobulin, one in the variable region and the remaining ones in the constant region.
2. A region of a protein having some distinctive physical feature or role.
3. An independently folded, globular structure composed of one section of a polypeptide chain. A domain may interact with another domain; it may be associated with a particular function. Domains can vary in size.
[Fr. domaine, fr. L. dominium, property, dominion]

domain

1. Of a protein, a discrete length of the amino acid sequence that is known to be associated with a specific function.
2. Of a chromosome, a region in which supercoiling occurs independently of other domains; or a region that includes a gene of raised sensitivity to degradation by DNASE I.

domain

  1. a structurally or functionally distinct part of a PROTEIN.
  2. any of three primary groupings (‘superkingdoms’): ARCHAEA, BACTERIA or EUCARYA, into which all ORGANISMS are placed in modern CLASSIFICATIONS based on genetic structures and sequences.

domain

1. region of a protein with a characteristic tertiary structure and function; homologous domains may occur on different proteins.
2. regions of the heavy chain of immunoglobulins. See cH domain, cL domain.

transmembrane domain
for any membrane-bound protein or glycoprotein, those amino acid sequences that traverse and are present in the cell membrane. In receptor biology, transmembrane domains are distinguished from the extracellular ligand binding domains, cytoplasmic domains, and from immunological domains.

Patient discussion about domain

Q. What other illnesses are similar to asthma? I am 45 years old. My doctor suspects I might have adult asthma but there has yet been a final diagnosis made. What other problems might this be?

A. Before diagnosing someone as asthmatic, alternative possibilities should be considered. A clinician taking a history should check whether the patient is using any known bronchoconstrictors (substances that cause narrowing of the airways, e.g., certain anti-inflammatory agents or beta-blockers). Chronic obstructive pulmonary disease, which closely resembles asthma, is correlated with more exposure to cigarette smoke, an older patient, and decreased likelihood of family history of atopy. Your physician should examine these possibilities as well before diagnosing.

More discussions about domain
References in periodicals archive ?
Comparison of functional domain of F protein with consensus sequences identified several amino acid substitutions in signal peptide with a single substitution, total of four substitutions in heptad repeat regions (HRa,HRb,HRc) and transmembrane domain had four substitutions.
G) Side and top views of the putative binding mode of p,p'-DDT and 16a in the transmembrane domain (TMD) of FSHR.
53) PIG-T is a 578-amino-acid protein with one transmembrane domain near the C-terminus.
Further studies have shown that the exact position of the lysine in DR[beta] is important as K225 within one amino acid from the transmembrane domain prevented MARCH8 from downregulating and ubiquitinating DR[beta], but MARCH8 was still able to downregulate DR[beta] when the K225 is moved between 2 and 7 amino acids away from the transmembrane domain.
Exon 1 encodes the 5' untranslated region (UTR) and the signal peptide, exons 2 and 3 encode most of the extracellular region of EPCR, and exon 4 encodes an additional 10 residues of the extracellular region of EPCR, the transmembrane domain, the cytoplasmic tail, and the 3' UTR (15), (17).
Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state.
The first transmembrane domain prediction methods still widely used exploit Kyte's & Doolittle's (Kyte & Doolittle 1982) hydropathy index.
City of Hope (Duarte, CA) has patented genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma.
In addition to a hydrophobic transmembrane domain, the cytoplasmic domain is organized into a membrane proximal constant domain (C1), a variable domain (V) with shared homology only between species, and a COOH terminal constant domain (C2) ending with a PDZ-binding motif (Lopes et al.
These ligands, like the receptors, are anchored on the plasma membrane via a glycosyl phosphatidylinositol linkage (ephrin-A) or a transmembrane domain (ephrin-B).
Exon 3 encoded a hydrophilic domain containing multiple stop codons that would result in truncation of MOG prior to translation of its transmembrane domain.
A histidine in the human GCSFR transmembrane domain is needed for activity, similar to what has been found for small-molecule hTPOR agonists

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