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A gene on chromosome 1p32-p31 that is the putative transforming gene of avian sarcoma virus 17, which interacts directly with specific target DNA sequences to regulate gene expression.

Molecular pathology
JUN maps to a chromosome region involved in both translocations and deletions in cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


A family of oncogenes that can transform some normal cells (e.g., rat embryo cells) into cancer cells. All members of this family can bind to activating protein-1 (AP-1) sites and to specific DNA sequences. See: oncogene; transformation
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.
The molecular mechanisms responsible for TPA-induced MMP-9 and IL-6 expression include binding of transcription factor AP-1 to its response element on the promoter regions of target genes.

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