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Related to Transcription factor AP-1: Sp1 transcription factor


A gene on chromosome 1p32-p31 that is the putative transforming gene of avian sarcoma virus 17, which interacts directly with specific target DNA sequences to regulate gene expression.

Molecular pathology
JUN maps to a chromosome region involved in both translocations and deletions in cancer.


A family of oncogenes that can transform some normal cells (e.g., rat embryo cells) into cancer cells. All members of this family can bind to activating protein-1 (AP-1) sites and to specific DNA sequences. See: oncogene; transformation
References in periodicals archive ?
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.
Tarenflurbil is a novel inhibitor of the transcription regulator NF-kB and the transcription factor AP-1, both of which are important regulators of inflammation.

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