TFAM

(redirected from Transcription factor 6)

TFAM

A gene on chromosome 10q21 that encodes a transcription factor which activates mitochondrial transcription and participates in mitochondrial genome replication. TFAM is required for regulating mitochondrial genome copy number and for embryonic development.

Molecular pathology
Targeted disruption of TFAM expression in mice results in physiological model of Kearns-Sayre syndrome.
References in periodicals archive ?
In model systems, UPR is activated by a set of transcription factors including activating transcription factor 6 (ATF6 (N)), X-box binding protein 1 (XBP1), and activating transcription factor 4 (ATF4) (Walter and Ron, 2011).
(2001 Identification of the G13 (cAMP-response-element-binding protein-related protein gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response.
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