HNF1B

(redirected from Transcription factor 2)

HNF1B

A gene on 17q12 that encodes a transcription factor that binds an inverted palindromic sequence of DNA.

Molecular pathology
Defects in HNF1B are a cause of maturity-onset diabetes of the young type 5 (MODY5, or renal cysts and diabetes syndrome) and contribute to the development of type-2 diabetes and prostate cancer hereditary type 11.
References in periodicals archive ?
Clinical andlaboratoryfindings of patients with thyroid dysgenesis Diagnosis Ectopia Athyreosis Hypoplasia F/M (*) 60/25 45/38 35/31 TSH (uIU/mL) (**) 76.2-500.0 36.1-440.0 13.0-100.0 (NR: 0.27-4.2) f[T.sub.4] (pmol/L) (**) 0.3-4.7 0.7-11.2 1.3-10.8 (NR: 12-22) PAX8 No mutation No mutation No mutation TTF1 No mutation No mutation No mutation TTF2 No mutation No mutation No mutation HHEX (#) 10 12 2 (*) F: female; M: male, (**) TSH: thyroid stimulating hormone, f[T.sub.4]: free thyroxine, NR: normal reference values, Minimal and maximal levels, (#) HHEX: have a variation of the intron 2 of HHEX, PAX8: paired box transcription factor 8, TTF1: thyroid transcription factor 1, TTF2: thyroid transcription factor 2, HHEX: hematopoietically-expressedhomeobox gene Table 2.
Activating Transcription Factor 2 (ATF2) Suppresses Skin Tumor Formation.
DeRossi et al., "Suppressor role of activating transcription factor 2 (ATF2) in skin cancer," Proceedings of the National Academy of Sciences of the United States of America, vol.

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