transcobalamin

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transcobalamin

 [trans″ko-bal´ah-min]
either of two plasma proteins, transcobalamin I and transcobalamin II, that bind and transport cobalamins, including vitamin B12 (see vitamin). Deficiency of transcobalamin II results in failure of immunoglobulin production, megaloblastic anemia, granulocytopenia, thrombocytopenia, and intestinal villous atrophy, and is correctable by vitamin B12 therapy.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive ?
An antibody against a vitamin B12-binding serum protein (transcobalamin II): a cause of high vitamin B12 in the serum of patients treated with delayed-action B12 preparations.
Turnover of [sup.57]Co-labelled vitamin B12-transcobalamin II and autologous [sup.131]I-labelled IgG in a patient with antibody to transcobalamin II. Scand J Haematol 1968;5:107-15.
Antibody to transcobalamin II and B12 binding capacity in patients treated with hydroxycobalamin.
Congenital deficiency of transcobalamin II. Blood 1975;45:71-82.
Hereditary partial transcobalamin II deficiency with neurologic, mental, and hematologic abnormalities in children and adults.
Isoelectric phenotype and relative concentration of transcobalamin II isoproteins related to the codon 259 Arg/Pro polymorphism.
Reduced vitamin [B.sub.12] binding by transcobalamin II increases risk of neural tube defects.
Quantitative methods for measurement of transcobalamin II. Methods Enzymol 1997;281:261-8.
Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults.
The role and fate of rabbit and human transcobalamin II in the plasma transport of vitamin B12 in the rabbit.
Changes in circulating transcobalamin II after injection of cyanocobalamin.