MAP3K8

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MAP3K8

An oncogene on chromosome 10p11.23 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway; it activates NF-kappaB 1 by stimulating proteasome-mediated proteolysis of NF-kappaB 1/p105.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
References in periodicals archive ?
It is therefore assumed that the waves measured at TPL-1 are also representative of the offshore conditions south of TPL-2.
As the tripod at TPL-2 was deployed later, the echosounder at that location started recording on 29 June 2013.
It is also visible for all three events that the vertical structure corresponding to the leading wave packet becomes more prominent at the TPL-2 location.
The top panel shows the original spectrograms at the TPL-1 and TPL-2 locations, whereas the bottom panels show the parts of the spectrogram where the PSD values are larger at TPL-1 than at TPL-2 (left-hand side), and vice versa (right-hand side panel).
For the Star wake, about 90% of the wave energy was conserved from TPL-1 to TPL-2.
The wake from the Superstar shows a similar reduction in divergent waves, whereas the contribution from the transverse waves was conserved from TPL-1 to TPL-2 (at about 3.
TPL-2] are water depths at the TPL1 and TPL-2 locations, respectively.