toxicokinetics

The study of the absorption, distribution, metabolism, and elimination of hazardous substances by an organism.

References in periodicals archive ?

Toxicokinetics of polar chemicals in zebrafish embryo (Danio rerio): Influence of physico-chemical properties and of biological processes.

Zebrafish Embryo and Acute Fish Toxicity Test Show Similar Sensitivity for Narcotic Compounds

Unfortunately, full mathematical representation of ANN and SVM models was not present in any of the evaluated articles reporting toxicokinetics endpoints.

Best Practices for QSAR Model Reporting: Physical and Chemical Properties, Ecotoxicity, Environmental Fate, Human Health, and Toxicokinetics Endpoints

The main goal of the present work was to investigate the bioconcentration and toxicokinetics of MC-LR in the gills of the two marine bivalves exposed to different MC-LR concentrations.

COMPARATIVE TOXICOKINETICS AND ANTIOXIDANT RESPONSE IN THE MICROCYSTIN-LR-EXPOSED GILL OF TWO MARINE BIVALVES, CRASSOSTREA GIGAS AND MYTILUS EDULIS

However, further studies evaluating the transplant of animals for a longer period are needed for a better understanding of Hg toxicokinetics in coastal environments.

Transplant Experiments as a Tool for Evaluating the Suitability of Sessile Organisms as Biomonitor Species in Tropical Coastal Waters: The Case of the Brown Mussel Perna perna (Linnaeus, 1758) in Rio de Janeiro State, Brazil

Due to the toxicokinetics and toxicodynamics of the toxic agents involved, exposure to organic solvents can trigger different behavioral and neurophysiological responses depending on gender (14).

Organic solvent exposure and contrast sensitivity: comparing men and women

Toxicokinetics studies were processed by DAS 2.1.1 software package (Chinese Pharmacological Society) to calculate half-life ([T.sub.1/2]), the maximum plasma concentration ([C.sub.max]), the corresponding time ([T.sub.max]), and the area under concentrationtime curve (AUC).

Renoprotective Effects of Total Glucosides from Paeony against Nephrotoxicity Induced by Total Alkaloids from Semen Strychni

Loperamide toxicokinetics: serum concentrations in the overdose setting.

Cardiac dysrhythmias after loperamide abuse--New York, 2008-2016

In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity.

Effect of Triazophos on Esterase Activity and Protein Contents of Liver, Kidney, Brain, Blood and Muscles of Catla catla, Labeo rohita and Cirrhinus mrigala

Toxicological study design considerations include species selection (default to rat and dog) and pharmacological considerations, compound metabolic/PK profile; testing of the quality of the drug candidate; formulation; dose-exposure linearity information; study duration; clinical endpoints (clinical observations, body weight, food consumption); pathology endpoints (clinical pathology and gross and histopathology) and toxicokinetics.

Moving from preclinical research to development

Early chapters examine molecular and cellular toxicology, covering topics on measuring toxicity and assessing risk; toxicokinetics, which is the phase of poisoning in which the poison undergoes movement within the body; biotransformation; cellular sites of action; genomics; and carcinogenesis.

Principles of Toxicology, 3rd Edition

Fumonisins: toxicokinetics, mechanism of action and toxicity.

Mycobiota and occurrence of Fumonisin [B.sub.1] in wheat harvested in Southern Brazil/Micobiota e ocorrencia de Fumonisina [B.sub.1] em trigo colhido no Sul do Brasil

The modeling topic of ENTOX mainly comprise (a) identification of the pathogen-pollutants and toxic stressor-effect relationship; (b) fate, behavior and transport of organic/non-organic toxic compounds degradation in exposure medium [2-4]; (c) absorption, distribution, metabolism and excretion of environmental contaminants within exposure sentinel species, human and animal [5-7]; (d) toxicokinetics (TK) and toxicodynamics (TD) mechanism at target sites [8]; and (e) risk assessment of toxic pollutant propagation from organisms to populations and variations in ecosystem sensitivities under various scenarios [5,9].