References in periodicals archive ?
The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information.
During a poster presentation at the American Society of Nephrology's (ASN) Kidney Week, Regulus will present preclinical results demonstrating the favorable pharmacokinetic and toxicokinetic properties of RG-012, an anti-miR targeting microRNA-21 ("miR-21") for the treatment of Alport syndrome, a life threatening disease with no approved therapy.
Toxicokinetic data indicated that the hepatotoxicity induced by triptolide is correlated with its highest concentration in the liver (Xue et al.
2013), or have quantified polymorphic toxicokinetic variation mainly in drug-metabolizing enzymes (Ginsberg et al.
Ethylene glycol poisoning: toxicokinetic and analytical factors affecting laboratory diagnosis.
Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.
Many, but certainly not all, of the sample analysis performed support pharmacokinetic (PK) and toxicokinetic (TK) studies.
The five chapters describe exposure estimation methods, toxicokinetic and toxicodynamic models, different approaches to mixture effects assessment, test design for mixture concentration-response analysis, and the differences between the whole mixture and component-based approaches to assessing the risk posed by chemical mixtures.
A column-switching high-performance liquid chromatographic assay for a novel cytotoxic thioxanthone derivative (WIN 33377) in mouse plasma with toxicokinetic results from a mouse LD10 study.
What's different here is that in addition to the usual array of biocompatibility tests it may be necessary to perform a toxicokinetic study in an in vivo test model in combination with physicochemical tests.
Using an international standard of hair to blood ratio of 250, a steady-state single compartment toxicokinetic model (2) (see equation 1) and a 5-fold uncertainty factor to account for inter-individual variability, Health Canada developed the pTDI for pregnant women, women of reproductive age and infants, set at 0.
Such models will facilitate more rigorous quantitative analysis of the available toxicokinetic data for Mn and will be used to identify situations that may lead to increased brain accumulation related to altered Mn metabolism in different human populations, and develop quantitatively accurate predictions of increased Mn levels that may serve as a basis of dosimetry-based risk assessment (79).