data are described within regulatory risk evaluation reports but are only used for the final assessment to a minor extent.
For example, one could use toxicokinetic
models [see, e.
To this end, this project will address different scientific and technical challenges as regards distribution, bioavailability, toxicokinetic
, and (bio)transformation products ((bio)TPs) of AFAs.
However, because of some limitations in the current study, we could not assess other hematological biomarkers such ferritin, and nor could we determine the usefulness as well as the pharmacokinetic and toxicokinetic
effects of iron oxide.
Margins of safety of intravascular contrast media: Body weight, surface area or toxicokinetic
Although there are few toxicokinetic
studies of heavy metals, it has been shown in rats that the oral absorption of Mn is increased when applied in inorganic forms and at elevated doses, which are easily transported through Mn-contaminated water and food (Dorman, Struve, James, McManus, Marshall, & Wong, 2001).
Phoenix is the most advanced, intuitive, and widely-used software for pharmacokinetic (PK), pharmacodynamic (PD), and toxicokinetic
(TK) modeling and simulation.
The Phoenix platform is used to manage, analyze and report PK, PD, and toxicokinetic
Moreover recent toxicokinetic
studies hypothesized that women (as case 2) generally absorb more and excrete less Co than men (as case 1) [22, 23].
data indicated that the hepatotoxicity induced by triptolide is correlated with its highest concentration in the liver (Xue et al.
of Organophosphorus Compounds, Department of Hydrobiology, Veterinary Division, National Research Center, 33El Bohouth st.
analysis of AFB1 revealed that it can be easily absorbed by the gastrointestinal tract and peritoneum  thus the concentration of AFB1 in plant products has been strictly limited by most countries.