toxicokinetics

(redirected from Toxicokinetic)

toxicokinetics

[tok′sikō′kinet′iks]
the passage through the body of a toxic agent or its metabolites, usually in an action similar to that of pharmacokinetics.

toxicokinetics

The study of the absorption, distribution, metabolism, and elimination of hazardous substances by an organism.
References in periodicals archive ?
Currently, toxicokinetic data are described within regulatory risk evaluation reports but are only used for the final assessment to a minor extent.
For example, one could use toxicokinetic models [see, e.
To this end, this project will address different scientific and technical challenges as regards distribution, bioavailability, toxicokinetic, and (bio)transformation products ((bio)TPs) of AFAs.
However, because of some limitations in the current study, we could not assess other hematological biomarkers such ferritin, and nor could we determine the usefulness as well as the pharmacokinetic and toxicokinetic effects of iron oxide.
Margins of safety of intravascular contrast media: Body weight, surface area or toxicokinetic approach?
Although there are few toxicokinetic studies of heavy metals, it has been shown in rats that the oral absorption of Mn is increased when applied in inorganic forms and at elevated doses, which are easily transported through Mn-contaminated water and food (Dorman, Struve, James, McManus, Marshall, & Wong, 2001).
Phoenix is the most advanced, intuitive, and widely-used software for pharmacokinetic (PK), pharmacodynamic (PD), and toxicokinetic (TK) modeling and simulation.
The Phoenix platform is used to manage, analyze and report PK, PD, and toxicokinetic (TK) data.
Moreover recent toxicokinetic studies hypothesized that women (as case 2) generally absorb more and excrete less Co than men (as case 1) [22, 23].
Toxicokinetic data indicated that the hepatotoxicity induced by triptolide is correlated with its highest concentration in the liver (Xue et al.
Zaki, Toxicokinetic of Organophosphorus Compounds, Department of Hydrobiology, Veterinary Division, National Research Center, 33El Bohouth st.
The toxicokinetic analysis of AFB1 revealed that it can be easily absorbed by the gastrointestinal tract and peritoneum [3] thus the concentration of AFB1 in plant products has been strictly limited by most countries.