Toxic thyroid adenoma

Toxic thyroid adenoma

Self-contained concentrations of thyroid tissue that may produce excessive amounts of thyroid hormone.
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A somatic mutation of TSHR gene (c.I703T>C) has been previously described in a patient who presented with a toxic thyroid adenoma and was demonstrated to have potent activation of the adenylate cyclase pathway [16 ].
About 5% of patients with thyrotoxicosis have toxic thyroid adenoma caused by excessive release of thyroid hormones.8
Moreover, three cases of Graves' disease without Graves' ophthalmopathy (after treatment of toxic thyroid adenomas) and one case of Graves' disease with severe Graves' ophthalmopathy (after treatment of mixed cystic-solid, nontoxic thyroid nodule) have been also reported [5].