Abstract: The fibrosing disorders represent a diverse group of uncommon chronic diseases that include systemic sclerosis, eosinophilic fasciitis, eosinophilia-myalgia syndrome, toxic oil syndrome, and localized forms of fibrosis.
In addition to systemic sclerosis, the prototype disorder, these conditions include EF, eosinophilia-myalgia syndrome, toxic oil syndrome, and localized forms of fibrosis.
The underlying cause of EF is unknown, although histologic findings, (6) as well as clinical similarities with toxic oil syndrome (7) and eosinophilia-myalgia syndrome, (8) suggest a possible toxic origin.
1) reported on the possible relationship between several genetic polymorphisms that regulate enzymatic activities involved in the processing of multiple xenobiotics and the risk of Spanish toxic oil syndrome (TOS).
Acetylator phenotype in patients with toxic oil syndrome and in normal controls.
In 1981, the Spanish toxic oil syndrome (TOS) affected more than 20,000 people, and over 300 deaths were registered.
Among food-related toxic outbreaks that have occurred in the world, the Spanish toxic oil syndrome (TOS) emerges as a significant disaster because of the degree of severity and the huge population involved (1,2).