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toxic doseTD50 Toxicology The calculated dose of a chemical introduced by a route other than inhalation, that would cause a specific toxic effect in 50% of a defined experimental animal population Cf Lethal concentration, Lethal dose.
tox·ic dose(toksik dōs)
Minimal dose required to produce adverse effects.
dose(dos) [Gr. dosis, a giving]
1. The amount of medicine or radiation administered.
2. The measurable exposure to an agent, e.g., to a poison, a quantity of radiation, or an irritant in the environment.
1. Radiation absorbed dose.
2. The amount of a substance ingested, inhaled, or taken up through any protective surface into the body
The intensity of radiation measured in air at the target.
Any dose, e.g., of a vaccine, administered to a neonate. The term is commonly used to describe a neonatal injection of hepatitis B vaccine.
A quantity of fluid or medicine given intravenously at a controlled, rapid rate.
booster doseSee: booster
collective doseSee: cumulative dose
1. The total medication or radiation dose to which an organism is exposed after repeated treatments.
2. The total ionizing radiation dose resulting from repeated exposures to an occupationally exposed individual over a period of time. This dose can be calculated for whole-body acute exposure or for specific organs or body parts, e.g., the hands.
3. The amount of a drug present in the body after repeated doses.
curative doseAbbreviation: CD
The dose required to heal an illness or disease.
The actual amount of radiation exposure at a specific point below the surface of the body.
The percentage by which blood urea nitrogen (BUN) is reduced during renal dialysis. Inadequate BUN reductions have been linked to increases in patient care costs, hospitalizations, and increased risk of death in patients with chronic renal failure. See: blood urea nitrogen
Fractional portions of a dose administered at specified intervals. For example, a patient may be given 2 g of cephalexin daily, divided as 500 mg orally every 6 hr.
A dose of one form of analgesic drug equivalent in pain-relieving effect to another analgesic. In pain control, this equivalence permits substitution of one analgesic to avoid undesired side effects from another.
equivalent doseAbbreviation: HT
The biologically active dose of radiation. The damage that a particular absorbed radiation dose will have on living cells and tissues.
erythema doseMinimal erythema dose.
A dose that kills.See: median lethal dose
The number of infectious organisms, esp. bacteria or viruses, that will cause disease in a healthy organism.
The dose of a substance that results in the death of cells, tissues, or the organism.
lethal dose lowAbbreviation: LDlo
The lowest dose of a substance that will kill at least one exposed organism.
The dose required to sustain a desired effect.
The largest dose that is safe to administer.
maximum permissible doseAbbreviation: MPD
The highest dose of radiation to which a person may be exposed over 1 year.
CAUTION!Each U.S. state sets limits on exposure to ionizing radiation. For example, for an adult over 18, the MPD is typically 5 rem (50 mSv). For a pregnant female, the MPD is limited to 0.5 rem (5 mSv).
maximum tolerated doseAbbreviation: MTD
The most extensive exposure to a treatment that a patient may receive before he or she experiences unbearable side effects.
mean marrow doseAbbreviation: MMD
An estimated measure of average radiation exposure given to the blood-forming progenitor cells of the bone marrow, e.g., in whole body radiation treatment. The percentage of active bone marrow in the useful beam is multiplied by the average absorbed dose.
median curative dose
A dose that cures half of all treated patients.
median infective doseAbbreviation: ID50
An infective dose that causes disease in half the subjects exposed to it.
median lethal doseAbbreviation: LD50
The amount of a substance, bacterium, or toxin that will kill 50% of the animals exposed to it. Dose is usually calculated on amount of material given per gram or kilogram of body weight or amount per unit of body surface area.See: minimum lethal dose
minimal erythema dose, minimum erythema dose Abbreviation: MED
The shortest exposure to ultraviolet radiation that produces reddening of the skin within 1 to 6 hr and disappears in 24 hr. The minimal erythemal dose is used to calculate the duration of therapeutic exposure to ultraviolet light. For treatment using a “hot” ultraviolet lamp (UV-A or UV-B), the dose is calculated at a distance of 30 in. The minimal erythemal dose for “cold” ultraviolet (UV-C) is standardized at 30 to 38 sec at a distance of 1 in. Synonym: erythema dose; threshold dose See: table
CAUTION!Burning, edema, and peeling occur at doses at or above the second degree erythemal dose.
|Suberythemal dose (SED)||No erythema|
|Minimal erythemal dose (MED)||Smallest dose that produces erythema within 1 to 6 hr and disappears within 24 hr|
|First degree erythemal dose (E1)||Erythema lasts for 1 to 3 days. Some scaling of the skin is present. E1 is approximately 2.5 times the MED.|
|Second degree erythemal dose (E2)||Erythema with associated edema, peeling, and pigmentation. E2 is approximately 5 times the MED.|
|Third degree erythemal dose (E3)||Severe erythema and burning with associated blistering, peeling, and edema. E3 is approximately 10 times the MED.|
The smallest effective dose.
minimum lethal dose
The smallest amount of a substance capable of producing death.See: median lethal dose
1. The number of nurses in the work force divided by the population of the community at large.
2. The number of nurses available for clinical responsibilities, divided by the quantity of those duties.
percentage depth dose
In radiation therapy, the ratio of the absorbed dose at a given depth to the absorbed dose at a fixed reference depth. It is dependent on four factors: energy, depth, field size, and source-to-skin distance.
An initial, large dose given to provide a high blood level as soon as possible.
1. Energy (joules) deposited by radiation in 1 kg of body tissue.
2. The exposure of a biological system to radiation, measured in rems or sieverts.
3. Radioactivity, measured in curies or becquerels.
4.See: radiation absorbed dose
radiation absorbed doseAbbreviation: rad
The quantity of ionizing radiation, measured in rad or gray (Gy), absorbed by any material, e.g., a person, per unit mass of matter. One Gy equals 100 rad.Synonym: absorbed dose
In cardioversion and defibrillation, the energy in joules selected to terminate an abnormal heart rhythm.
A radiation dose to the skin including secondary radiation from backscatter.
A dose containing not quite enough of a toxin or noxious substance to cause death.
stress doseStress dosage.
1. A low dose of a medication given to assess its safety or tolerability.
2. A small dose given to determine its precise effect on living tissues.
The dose required to produce the desired effect.
threshold doseSee: minimal erythema dose
tissue culture infective doseAbbreviation: TCID50
The dose that will produce a cytopathic effect in 50% of the cultures inoculated.
tissue tolerance dose
The largest dose, esp. of radiation, that will not cause obvious or immediate disfunction in tissues.
The dose of a drug or physical agent, e.g., radiation, that will not cause perceptible or immediate injury. This dose will vary among individuals.
A poisonous dose.
A dose of medicine prepared in an individual packet for convenience, safety, or monitoring.Synonym: monodose